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Isocarboxazid Pregnancy and Breastfeeding Warnings

Isocarboxazid is also known as: Marplan

Isocarboxazid Pregnancy Warnings

The Collaborative Perinatal Project monitored 21 mother-child pairs exposed to monoamine oxidase inhibitors during the first trimester of pregnancy; one of which was exposed to isocarboxazid. An increased risk of malformation was observed, however details were not given.

Isocarboxazid has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Isocarboxazid is only recommended for use during pregnancy when benefit outweighs risk.

Isocarboxazid Breastfeeding Warnings

There are no data on the excretion of isocarboxazid into human milk. The effects in the nursing infant are unknown. The manufacturer recommends that isocarboxazid be used in nursing women only if clearly needed.

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