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Isocarboxazid Pregnancy and Breastfeeding Warnings

Isocarboxazid is also known as: Marplan

Isocarboxazid Pregnancy Warnings

Adequate animal studies have not been performed. There are no controlled data in human pregnancy. The molecular weight (about 231) is low enough that fetal exposure should be expected. The Collaborative Perinatal Project monitored 21 mother-child pairs exposed to monoamine oxidase inhibitors during the first trimester of pregnancy; one of which was exposed to isocarboxazid. An increased risk of malformation was observed, however details were not given. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Use should be avoided, especially during the first and last trimesters of pregnancy; this drug should be used during pregnancy only if clearly needed. US FDA pregnancy category: C

See references

Isocarboxazid Breastfeeding Warnings

Use is contraindicated. (UK) This drug should be used only if clearly needed. (US) Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: -Because of its low molecular weight, excretion into breast milk is expected.

See references

References for pregnancy information

  1. "Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
  2. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. "Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):

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