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Hydrochlorothiazide / quinapril Pregnancy and Breastfeeding Warnings

Hydrochlorothiazide / quinapril is also known as: Accuretic, Quinaretic

Hydrochlorothiazide / quinapril Pregnancy Warnings

-Use is contraindicated. (AU, UK) -This drug should not be used in pregnancy unless the benefit outweighs the risk to the fetus. (US) AU TGA pregnancy category: D US FDA pregnancy category: D Comments: -Adequate methods of contraception should be encouraged. -If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.

-Data have shown an association between major congenital malformations and the use of ACE inhibitors during the first trimester. The use of drugs that act directly on the renin-angiotensin system during the second and third trimesters of pregnancy has been associated with fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death. Oligohydramnios has also been reported, presumably resulting from decreased fetal limb contractures, craniofacial deformation, and hypoplastic lung development. Prematurity, intrauterine growth retardation, and patent ductus arteriosus have also been reported, although it is not clear whether these occurrences were due to exposure to the drug. -Mothers whose embryos and fetuses are exposed to an ACE inhibitor during the first trimester should be informed of the risks. When pregnancy is detected or expected, this should be discontinued as soon as possible. -Cases of neonatal thrombocytopenia associated with antepartum administration of thiazide diuretics have been reported. AU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects. Accompanying texts should be consulted for further details. US FDA pregnancy category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Hydrochlorothiazide / quinapril Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Yes (hydrochlorothiazide, quinapril) The effects in the nursing infant are unknown.

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