Fosamprenavir Pregnancy and Breast Feeding Warnings
Fosamprenavir is also known as: Lexiva, Telzir
Overview
If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fosamprenavir while you are pregnant. It is not known if Fosamprenavir is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Fosamprenavir to the baby.
Fosamprenavir Pregnancy Warnings
Fosamprenavir has been assigned to pregnancy category C by the FDA. Administration of fosamprenavir to pregnant rats and rabbits produced no major effects on embryo-fetal development. However, the incidence of abortion was increased in rabbits that were administered fosamprenavir. There are no controlled data in human pregnancy. Fosamprenavir is only recommended for use during pregnancy when benefit outweighs risk.
An Antiretroviral Pregnancy Registry has been established to monitor maternal-fetal outcomes of pregnant women exposed to fosamprenavir. Physicians are encouraged to register patients by calling 1-800-258-4263 (USA).
Fosamprenavir Lactation Warnings
There are no data on the excretion of amprenavir into human milk following administration of fosamprenavir. Amprenavir is excreted into the milk of lactating rats. The manufacturer recommends that due to the potential for HIV transmission and the potential for serious adverse reactions in nursing infants, mothers should not breast-feed while taking fosamprenavir. The U.S. Public Health Service Centers for Disease Control and Prevention advise HIV-infected women not to breast-feed to avoid postnatal transmission of HIV to a child who may not yet be infected.
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