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Ethionamide Pregnancy and Breastfeeding Warnings

Ethionamide is also known as: Trecator, Trecator-SC

Ethionamide Pregnancy Warnings

Ethionamide has been assigned to pregnancy category C by the FDA. Animal studies with high doses have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Seven cases of birth defects have been reported (23 exposed infants) in one study. The manufacturer recommends that ethionamide not be used in women who are pregnant or likely to become pregnant, unless it is considered an essential part of the regimen. Guidelines published by the American Thoracic Society, Centers for Disease Control, and Infectious Diseases Society of America recommend that ethionamide be avoided during pregnancy.

Ethionamide Breastfeeding Warnings

There are no data on the excretion of ethionamide into human milk. Due to its low molecular weight, excretion is expected. The manufacturer recommends that ethionamide be given to nursing mothers only if the benefits outweigh the risks. Breast-fed neonates should be monitored for adverse effects.

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