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Estradiol topical Pregnancy and Breastfeeding Warnings

Estradiol topical is also known as: Estrace Vaginal Cream, Estring, Vagifem

Overview

Do not use Estradiol Cream if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estradiol Cream is found in breast milk. If you are or will be breast-feeding while you use Estradiol Cream, check with your doctor. Discuss any possible risks to your baby.

Estradiol topical Pregnancy Warnings

Estrogens have been assigned to FDA pregnancy category X. Estrogens are contraindicated for use during pregnancy. Estrogenic agents have been associated with urogenital abnormalities in offspring that manifest later in life. Vaginal adenosis, squamous cell dysplasia of the uterine cervix and vaginal cancer have developed later in life in female offspring. In the male offspring, the risks of urogenital abnormalities and testicular cancer later in life are increased.

Estradiol topical Breastfeeding Warnings

Limited data are available on the excretion of estradiol into human milk. The American Academy of Pediatrics considers estradiol to be usually compatible with breast-feeding despite reports of "withdrawal" and "vaginal bleeding". Estradiol has been shown to decrease to quantity and quality of the milk. Estrogens are not indicated for the prevention of postpartum breast engorgement. The manufacturer recommends that caution be used when administering estradiol to nursing women.

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