Estradiol / medroxyprogesterone Pregnancy and Breastfeeding Warnings

Estradiol / medroxyprogesterone is also known as: Lunelle

Estradiol / medroxyprogesterone Pregnancy Warnings

Estradiol-medroxyprogesterone injection has been assigned to pregnancy category X by the FDA. Although some reports have suggested that oral contraceptive hormones may cause a variety of congenital malformations, recent studies (including a meta-analysis of prospective studies) have suggested that an association between oral contraceptive use and congenital malformations does not exist. Some progestins may cause masculinization of female infants. There is no indication for the use of estradiol-medroxyprogesterone injection during pregnancy. Estradiol-medroxyprogesterone injection is contraindicated for use during pregnancy.

Estradiol / medroxyprogesterone Breastfeeding Warnings

There are no data on the excretion of estradiol-medroxyprogesterone injection into human milk. Both the estrogens and progestins occurring in commercially available oral contraceptive formulations are excreted into human milk in very small amounts. The American Academy of Pediatrics considers use of oral contraceptive combinations to be compatible with breast-feeding despite rare reports of breast enlargement in the nursing infant and the possibility of a decrease in milk production and protein content.

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