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Ergocalciferol Pregnancy and Breastfeeding Warnings

Ergocalciferol is also known as: Calcidol, Calciferol, Drisdol, Vitamin D2

Ergocalciferol Pregnancy Warnings

Ergocalciferol (vitamin D2) has been assigned to pregnancy category C. When used within the recommended daily allowance for pregnant women, ergocalciferol is considered to be safe. The recommended daily allowance of vitamin D in pregnant women is 400 to 600 intl units. High doses of other vitamin D analogs have been shown to be teratogenic, resulting in external and skeletal abnormalities. Ergocalciferol should only be used during pregnancy when benefit outweighs the risk.

Supplementation of vitamin D during the third trimester with vitamin D2 or vitamin D3 has been studied. Dosages of 1000 intl units per day given daily during the third trimester did not result in any adverse fetal outcome. Neonatal calcium homeostasis was affected, resulting in significantly higher concentrations of calcium, 25-OH vitamin D3, and 1,25-(OH)2 vitamin D3. Earlier literature expressed concerns over the development of supravalvular aortic stenosis, craniofacial abnormalities, and dental abnormalities in infants and children with idiopathic hypercalcemia. Whether or not prenatal factors predisposed these children to the development of hypercalcemia is not known. Fifteen hypoparathyroid women receiving 50,000 to 250,000 Intl units of vitamin D2 experienced 27 uneventful births. No cardiovascular or craniofacial abnormalities were reported.

Ergocalciferol Breastfeeding Warnings

The American RDA for vitamin D in the lactating woman is 400 to 600 intl units. Vitamin D supplements may be necessary if maternal vitamin D nutrition is insufficient. The American Academy of Pediatrics considers ergocalciferol or vitamin D2 to be compatible with breast-feeding. If the mother is receiving pharmacological doses, serum calcium levels in the breast-fed infant should be monitored.

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