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Drospirenone / ethinyl estradiol Pregnancy and Breastfeeding Warnings

Drospirenone / ethinyl estradiol is also known as: Gianvi, Loryna, Nikki, Ocella, Syeda, Vestura, Yasmin, Yaz, Zarah

Drospirenone / ethinyl estradiol Pregnancy Warnings

Drospirenone-ethinyl estradiol has been assigned to pregnancy category X by the FDA. Oral contraceptive combinations are contraindicated for use during pregnancy.

Drospirenone/ethinyl estradiol should not be used during pregnancy. Fourteen pregnancies that occurred with medication exposure in utero have been identified. One infant was born with esophageal atresia. A causal association between the drug and the side effect is unknown.

Drospirenone / ethinyl estradiol Breastfeeding Warnings

The manufacturer reports that about 0.02% of the dose of drospirenone is excreted into the breast milk of postpartum women within 24 hours. This results in a maximal daily dose of about 3 mcg drospirenone in an infant.

Drospirenone-ethinyl estradiol is excreted in human breast milk. Jaundice and breast enlargement have been reported in infants exposed to steroid contraceptives excreted in human milk. The manufacturer suggests that other forms of contraception be used if possible until the infant has been weaned from the mother.

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