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Doxorubicin liposomal Pregnancy and Breastfeeding Warnings

Doxorubicin liposomal is also known as: Doxil, Lipodox, Lipodox 50

Doxorubicin liposomal Pregnancy Warnings

The following information regarding doxorubicin in pregnancy was not from use of the liposomal form. Doxorubicin crosses the human placenta. Several cases of birth defects have been associated with the use of doxorubicin during pregnancy. These birth defects have included imperforate anus, rectovaginal fistula, brachycephaly, hypoplasia of the anterior cranial base and face, synostoses of cranial sutures, hypoplastic digits, and fetal maceration. Fetal death has been reported 36 hours after treatment with doxorubicin and other neoplastic agents. Doxorubicin may cause reversible testicular and ovarian dysfunction or menstrual abnormalities. Most men who have received doxorubicin regain spermatogenesis and sperm motility. Some women who were previously treated with doxorubicin have subsequently had normal pregnancies. Development of sterility may depend on the dose, duration of therapy, and the pretreatment state of gonadal function. Pregnancy outcome in women who received doxorubicin for malignancy in childhood has been reported to generally be favorable. Those with baseline left ventricular dysfunction should be considered at increased risk for worse pregnancy outcome and further deterioration in myocardial function. Peripartum heart failure has been reported years after doxorubicin therapy. Pregnancy, preeclampsia, anemia, or overhydration are possible precipitating factors in the emergence of heart failure in patients who have received doxorubicin.

Doxorubicin liposomal has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity and abortifacient activity. Several cases of birth defects have been associated with the use of doxorubicin. There are no controlled data in human pregnancy. Women should be advised to avoid pregnancy. The prolonged half-life of doxorubicin liposomal should be considered if a woman becomes pregnant in the first few months following treatment.

Doxorubicin liposomal Breastfeeding Warnings

There are no data on the excretion of doxorubicin liposomal into human milk. However, conventional doxorubicin is excreted into and accumulates in human milk. Side effects, including immune suppression, carcinogenesis, neutropenia, and unknown effects on growth are possible in nursing infants. The manufacturer recommends discontinuing nursing during treatment with doxorubicin liposomal. The American Academy of Pediatrics considers the use of doxorubicin to be contraindicated during breast-feeding.

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