Dopamine Pregnancy and Breastfeeding Warnings
Dopamine is also known as: Intropin
Dopamine Pregnancy Warnings
Dopamine has been assigned to pregnancy category C by the FDA. Animal studies have shown a decrease in survival rate of newborn rats and potential for cataract formation for the survivors. There are no controlled data in human pregnancy. Dopamine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.
Based on data from animal studies, increased uterine resistance is expected in humans. Low dose dopamine (1 to 5 mcg per kg per minute), however, has been used safely to increase urine output in six oliguric women with preeclampsia without significantly altering maternal central venous or pulmonary capillary wedge blood pressures or causing fetal harm. It has also been safely used to treat hypotension in pregnant women during Cesarean section without causing adverse effects in the fetuses, newborns, or mothers.
Dopamine Breastfeeding Warnings
There are no data on the excretion of dopamine into human milk. The manufacturer recommends that caution be used when administering dopamine to nursing women.
References for pregnancy information
- Fishburne JI, Dormer KJ, Payne GG, Gill PS, Ashrafzadeh AR, Rossavik IK "Effects of amrinone and dopamine on uterine blood flow and vascular responses in the gravid baboon." Am J Obstet Gynecol 158 (1988): 829-37
- Kirshon B, Lee W, Mauer MB, Cotton DB "Effects of low-dose dopamine therapy in the oliguric patient with preeclampsia." Am J Obstet Gynecol 159 (1988): 604-7
References for breastfeeding information
- "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals, Wilmington, DE.
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