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Dinoprostone topical Pregnancy and Breastfeeding Warnings

Dinoprostone topical is also known as: Cervidil, Prepidil, Prostin E2

Dinoprostone topical Pregnancy Warnings

Dinoprostone topical has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryotoxicity, and any dose that produces sustained increased uterine tone could put the embryo or fetus at risk. Prostaglandin E2 has produced an increase in skeletal anomalies in rats and rabbits. No effects would be expected clinically, when used as indicated, since dinoprostone vaginal insert and cervical gel are administered after the period of organogenesis. Animal studies have failed to reveal evidence of teratogenicity with dinoprostone vaginal suppository. Dinoprostone topical is only recommended for use during pregnancy when benefit outweighs risk.

Dinoprostone topical Breastfeeding Warnings

There are no data on the excretion of dinoprostone topical into human milk.

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