Home › Drugs by Condition › S › SIADH › Demeclocycline Pregnancy Warnings
Print Save or Share

Demeclocycline Pregnancy and Breastfeeding Warnings

Demeclocycline is also known as: Declomycin

Overview

Demeclocycline has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Demeclocycline during pregnancy. Demeclocycline is found in breast milk. Do not breast-feed while taking Demeclocycline.

Demeclocycline Pregnancy Warnings

Demeclocycline has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity and teratogenicity associated with the use of tetracyclines. Demeclocycline crosses the placenta with cord concentrations averaging 65% of maternal blood levels. There are no controlled data in human pregnancies; however, congenital defects associated with the use of tetracyclines has been reported, including toxic effects on skeletal formation. When used during tooth development (second half of pregnancy) tetracyclines may cause permanent yellow-gray-brown discoloration of the teeth and enamel hypoplasia. Demeclocycline should only be given with extreme caution, if at all, during pregnancy. Demeclocycline is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk. Pregnant patients or patients who become pregnant during demeclocycline therapy should be advised of the potential hazards to the fetus.

Demeclocycline Breastfeeding Warnings

There are no data on the excretion of demeclocycline into human milk; however, tetracyclines are excreted into human milk in small amounts. Concentrations of tetracycline in milk have averaged 0.6 mcg/mL when the blood level was approximately 1.2 mcg/mL. The theoretical risks of dental staining and inhibition of bone growth exist, although they are unlikely. In one study, tetracycline levels were undetectable in nursing infants. Tetracycline, a related drug, is considered compatible with breast-feeding by the American Academy of Pediatrics. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

(web3)