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Cytarabine liposomal Pregnancy and Breastfeeding Warnings

Cytarabine liposomal is also known as: DepoCyt

Cytarabine liposomal Pregnancy Warnings

Cytarabine liposomal has been assigned to pregnancy category D by the FDA. Animal studies of cytarabine have revealed evidence of teratogenicity and embryotoxicity. There are no controlled data in human pregnancy. Following the intravenous administration of cytarabine (the active component of cytarabine liposomal), three anecdotal cases of major limb malformations have been reported. However, the manufacturer of cytarabine liposomal has stated that the concern for fetal harm following intrathecal cytarabine liposomal is low because systemic exposure to cytarabine is negligible. Cytarabine liposomal should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Cytarabine liposomal Breastfeeding Warnings

There are no data on the excretion of cytarabine liposomal into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, the use of cytarabine liposomal is not recommended in nursing women.

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