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Cyproheptadine Pregnancy and Breastfeeding Warnings

Cyproheptadine is also known as: Periactin

Cyproheptadine Pregnancy Warnings

Cyproheptadine, an antiserotonin agent, has been studied in habitual aborters with increased serotonin levels. No malformations have been reported. One woman treated with cyproheptadine for Cushing's syndrome through the first trimester gave birth to a healthy infant. Another woman treated throughout pregnancy gave birth to a normal infant which died at 4 months of gastroenteritis.

Cyproheptadine has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Cyproheptadine is only recommended for use during pregnancy when benefit outweighs risk.

Cyproheptadine Breastfeeding Warnings

There are no data on the excretion of cyproheptadine into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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