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Conjugated estrogens Pregnancy and Breastfeeding Warnings

Conjugated estrogens is also known as: Cenestin, Enjuvia, Premarin, Premarin Intravenous

Conjugated estrogens Pregnancy Warnings

Conjugated estrogens have been assigned to pregnancy category X by the FDA. An increase in the frequency of congenital malformations has been associated with use of estrogenic substances in pregnancy. Other estrogenic agents have been associated with the development of vaginal adenosis, squamous cell dysplasia of the uterine cervix and vaginal cancer later in life. There is no indication for the use of conjugated estrogens during pregnancy. Conjugated estrogens use is considered contraindicated during pregnancy.

Specific categories of malformations include cardiovascular defects, hypospadias, eye and ear malformations and Downs syndrome.

Conjugated estrogens Breastfeeding Warnings

There are no data on the excretion of conjugated estrogens into human milk. The American Academy of Pediatrics considers estradiol, another estrogenic agent, to be compatible with breast-feeding despite reports of "withdrawal" and "vaginal bleeding". (No other information about those reports is available.) The manufacturer recommends that caution be used when administering conjugated estrogens to nursing women.

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