Cisapride Pregnancy and Breastfeeding Warnings

Cisapride is also known as: Propulsid

Cisapride Pregnancy Warnings

Cisapride has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity, although embryo- and fetotoxicity are seen in rats and rabbits at high doses (150 mg/kg/day and 20 mg/kg/day, respectively). There are no controlled data in human pregnancy. Cisapride should only be given during pregnancy when benefit outweighs risk.

Cisapride Breastfeeding Warnings

Cisapride is excreted into human milk in small amounts. The manufacturer recommends cautious use during lactation. However, cisapride is considered compatible with breast-feeding by the American Academy of Pediatrics.

In a study of ten puerperal women administered cisapride 20 mg by mouth three times a day for 4 days, cisapride milk concentrations averaged 6.2 ng/mL, with corresponding serum concentrations averaging 137 ng/mL one hour after the last dose.

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