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Carbidopa / levodopa Pregnancy and Breastfeeding Warnings

Carbidopa / levodopa is also known as: Atamet, Parcopa, Sinemet, Sinemet CR

Carbidopa / levodopa Pregnancy Warnings

One study has reported that single oral doses of levodopa administered to pregnant women resulted in decreased plasma renin activity, decreased plasma aldosterone and decreased plasma prolactin.

Levodopa-carbidopa formulations have been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of visceral and skeletal malformations in rabbits at doses 5 to 20 times the maximum recommended human dose of levodopa-carbidopa. There are no controlled data in human pregnancy. Two reports have described three patients who received levodopa or levodopa-carbidopa throughout pregnancy without evidence of fetal harm. Levodopa-carbidopa is only recommended for use during pregnancy when benefit outweighs risk.

Carbidopa / levodopa Breastfeeding Warnings

There are no data on the excretion of levodopa or carbidopa into human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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