Questions about Rheumatoid Arthritis? Get answers from our expert.

Calcitonin Pregnancy and Breastfeeding Warnings

Calcitonin is also known as: Calcimar, Fortical, Miacalcin, Miacalcin Nasal

Calcitonin Pregnancy Warnings

Calcitonin has been assigned to pregnancy category C by the FDA. Animal studies using synthetic salmon calcitonin have shown a decrease in fetal birth weights when rabbits were given doses 14 to 56 times the recommended human dose. There are no controlled data in human pregnancy. Calcitonin is only recommended for use during pregnancy when benefit outweighs risk.

Animal studies suggest that calcitonin does not cross the placental barrier. Maternal calcitonin levels increase during pregnancy. These levels are not correlated with serum calcium or phosphate except when inversely proportional to the serum phosphate during the first trimester. The significance of this rise to the fetus is unknown.

Calcitonin Breastfeeding Warnings

Calcitonin is found as a normal constituent of human milk, both in normal and thyroidectomized women. Levels are about 40 times that found in serum. Calcitonin is a peptide and is likely digested in the gastrointestinal tract of the infant. However, studies of drug activity after ingestion have not been done in nursing infants. Exogenous calcitonin has been shown to inhibit lactation in animal studies.

There are no data on the excretion of calcitonin into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web1)