Atropine / difenoxin Pregnancy and Breastfeeding Warnings

Atropine / difenoxin is also known as: Motofen

Atropine / difenoxin Pregnancy Warnings

Atropine-difenoxin has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity however pregnant rats receiving 20 times the maximum human dose had an increase in delivery time as well as a significant increase in the percent of stillbirths. There are no controlled data in human pregnancy. Atropine-difenoxin is only recommended for use during pregnancy when the potential benefit justifies the potential risk to the fetus.

Atropine / difenoxin Breastfeeding Warnings

There are no data on the excretion of atropine-difenoxin into human milk. The effects in the nursing infant are unknown. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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