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Atovaquone Pregnancy and Breastfeeding Warnings

Atovaquone is also known as: Mepron

Overview

If you become or plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Atovaquone while pregnant. It is not known if Atovaquone is found in breast milk. If you are or will be breast-feeding while you are using Atovaquone, check with your doctor. Discuss any possible risks to your baby.

Atovaquone Pregnancy Warnings

Atovaquone has been assigned to pregnancy category C. Animal studies have revealed evidence of increased resorption and fetal harm; it is unclear if these effects were due to direct embryotoxicity and fetotoxicity or secondary to maternal toxicity. There are no controlled data in human pregnancies. Atovaquone should only be given during pregnancy when benefit outweighs risk.

Atovaquone Breastfeeding Warnings

There are no data on the excretion of atovaquone into human milk. In a rat study, atovaquone milk concentration was 30% of maternal plasma concentration. The manufacturer recommends that caution be used when administering atovaquone to nursing women. The U.S. Public Health Service Centers for Disease Control and Prevention advise HIV-infected women not to breast-feed to avoid postnatal transmission of HIV to a child who may not yet be infected.

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