Amprenavir Pregnancy and Breast Feeding Warnings
Amprenavir is also known as: Agenerase
Overview
Do not use Amprenavir Solution if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if Amprenavir Solution is excreted in breast milk. Do not breast-feed while taking Amprenavir Solution. HIV-infected mothers should not breast-feed their infants because of the risk of transmitting the HIV infection or Amprenavir Solution.
Amprenavir Pregnancy Warnings
Amprenavir has been assigned to pregnancy category C by the FDA. High-dose animal studies have revealed evidence of an increased incidence of abortions, skeletal variations due to incomplete ossification of bones, thymic elongation, and reduced body weights. There are no controlled data in human pregnancy. Amprenavir should only be given during pregnancy when benefit outweighs risk. The oral solution of amprenavir is contraindicated during pregnancy due to the potential risk of toxicity to the fetus from the high propylene glycol content.
An Antiretroviral Pregnancy Registry has been to monitor maternal-fetal outcome of amprenavir exposures during pregnancy. To register patients, physicians should call 1-800-258-4263 (USA).
Amprenavir Lactation Warnings
There are no data on the excretion of amprenavir into human milk. It is excreted into rat milk. HIV-infected mothers should not breast-feed their infants due to the risk of transmission of HIV via breast milk.
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