Trypsin / Balsam Peru / Castor Oil

Pronunciation: TRIP-sin/BOLL-sam peh-RUH/KASS-ter oil
Class: Enzyme combination, topical

Trade Names

Granulex
- Aerosol 0.12 mg trypsin/87 mg balsam Peru/788 mg castor oil per g

Optase
- Gel 0.12 mg tyrpsin/87 mg balsam Peru/788 mg castor oil per g

Pharmacology

Physiologically debrides tissue; improves epithelization by reducing premature epithelial desiccation and cornification.

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Indications and Usage

In acute and chronic conditions such as varicose ulcers, decubital ulcers, eschar, dehiscent wounds and sunburn, relieves pain and promotes healing; debrides eschar and necrotic tissue; stimulates vascular bed; improves epithelization; reduces odor from necrotic wounds.

Contraindications

None well documented.

Dosage and Administration

Topical

Apply a minimum of twice daily or as often as necessary.

General Advice

  • For external use only. Avoid contact with eyes.
  • Shake aerosol can well and hold upright approximately 12 inches from the area to be treated.
  • Do not apply to fresh arterial clots.
  • The wound may be left unbandaged or appropriate dressing applied.
  • To remove, wash gently.

Storage/Stability

Store between 59° and 86°F. Avoid freezing. Do not expose aerosol can to temperatures above 120°F. Do not expose aerosol can to fire or open flame.

Drug Interactions

None well documented.

Adverse Reactions

Dermatologic

Stinging or burning sensation; irritation.

Precautions

Pregnancy

Category undetermined.

Lactation

Undetermined.

Patient Information

  • Advise patient, family, or caregiver that medication will usually be prepared and applied by a health care provider in a medical setting but may also be used in a home environment.
  • Review prescribed dosing schedule and application process with patient, parent, or caregiver.
  • Advise patient, parent, or caregiver that spray may produce a temporary stinging sensation when applied to sensitive skin, but that this should be tolerable. If it persists or is intolerable, notify health care provider.

Copyright © 2009 Wolters Kluwer Health.

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