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A-Z Drug Facts > Tiludronate Disodium

Tiludronate Disodium

Pronouncation: (tie-LOO-droe-nate)
Class: Bisphosphonate

Trade Names:
Skelid
- Tablets 240 mg (eq. to 200 mg tiludronic acid)

Pharmacology

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Inhibits normal and abnormal bone resorption.

Pharmacokinetics

Absorption

Tiludronate bioavailability is 6%. In clinical studies, efficacy was seen when dosed at least 2 h before or after meals. Tiludronate C max is 3 mg/L; T max occurs with 2 h of dose.

Distribution

Tiludronate is widely distributed in bones and soft tissue and is about 90% bound to proteins.

Elimination

The primary route of elimination is in urine. Approximately 60% of a dose is excreted in urine. Tiludronate t ½ is 150 h.

Special Populations

Renal Function Impairment

Tiludronate is not recommended for patients with severe renal failure (CrCl less than 30 mL/min) because of lack of clinical experience.

Indications and Usage

Treatment of Paget disease of bone.

Contraindications

Standard considerations.

Dosage and Administration

Adults

PO 400 mg every day for 3 mo.

Storage/Stability

Store at controlled room temperature. Do not remove from foil strip until ready for administration.

Drug Interactions

Aspirin, calcium, aluminum- or magnesium-containing antacids

Decrease tiludronate bioavailability.

Indomethacin

Increases tiludronate bioavailability.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Hypertension; syncope.

CNS

Paresthesia; vertigo; somnolence; anxiety; nervousness; insomnia; involuntary muscle contractions.

Dermatologic

Rash; pruritus; sweating.

EENT

Cataract; conjunctivitis; glaucoma; rhinitis; sinusitis; pharyngitis.

GI

Diarrhea; nausea; constipation; vomiting; flatulence; abdominal pain; anorexia; dry mouth; gastritis.

Metabolic

Hyperparathyroidism.

Miscellaneous

Fatigue; asthenia; chest pain; edema; arthrosis; flushing.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Renal Function

Not recommended in patients with CrCl less than 30 mL/min.

Overdosage

Symptoms

Hypocalcemia.

Patient Information

  • Instruct patient to take drug with 6 to 8 oz of plain water. Advise patient to not use any other beverage (eg, mineral water).
  • Instruct patient to avoid eating 2 h before and 2 h after taking medication since absorption of drug is reduced by food.
  • Instruct patient to maintain adequate intake of vitamin D and calcium.
  • Advise patient to take calcium or mineral supplements 2 h before or 2 h after tiludronate.
  • Advise patient to take aluminum- or magnesium-containing antacids at least 2 h after tiludronate.
  • Advise patients taking aspirin or indomethacin to take these 2 h before or after tiludronate.
  • Advise patient to not remove medication from foil strip until just before administration.



Compare Tiludronate Disodium with other medications for the treatment of:

Paget's Disease

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