Sodium Sulfacetamide / Sulfur
Pronouncation: (SO-dee-uhm sul-fah-SEE-tah-mide/SULL-fer)Class: Keratolytic agent
Trade Names:
Avar
- Cleanser 10% sodium sulfacetamide and 5% sulfur
- Gel 10% sodium sulfacetamide and 5% sulfur
Trade Names:
Clenia
- Cream 10% sodium sulfacetamide and 5% sulfur
- Foam 10% sodium sulfacetamide and 5% sulfur
Trade Names:
Rosula
- Gel 10% sodium sulfacetamide and 5% sulfur
Trade Names:
Sulfacet-R
- Lotion 10% sodium sulfacetamide and 5% sulfur
Trade Names:
Zetacet
- Topical suspension 10% sodium sulfacetamide and 5% sulfur
Pharmacology
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Competitively antagonizes PABA, an essential component of folic acid synthesis.
SulfurInhibits the growth of Propionibacterium acnes and the formation of free fatty acids.
Indications and Usage
Topical control of acne vulgaris, acne rosacea, and seborrheic dermatitis.
Contraindications
Kidney disease; known hypersensitivity to sulfonamides, sulfur, or any component of the product.
Dosage and Administration
Adults and children 12 yr of age and olderTopical Apply a thin film to affected areas once to 3 times daily with light massaging to blend in each application.
Storage/Stability
Store at controlled room temperature (59° to 86°F). Keep bottle tightly closed.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
Dermatologic
Local irritation; dryness; erythema; itching.
Miscellaneous
Allergic hypersensitivity.
Precautions
Pregnancy
Category C .
Lactation
Undetermined; however, small amounts of orally administered sulfonamides are secreted in breast milk.
Children
Safety and efficacy not determined in children younger than 12 yr of age.
Irritation
If irritation develops, discontinue use and institute appropriate therapy.
Sensitivity
May occur; use caution and careful supervision when prescribing this drug for patients who may be prone to hypersensitivity to topical sulfonamides.
Sodium metabisulfite
May contain sodium metabisulfite, which can cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in susceptible individuals.
Patient Information
- Review prescribed dosing schedule with patient or caregiver.
- Remind patient or caregiver that product is not to be used in the eye or ear.
- Teach patient or caregiver proper technique for applying product: wash hands; shake lotion and suspension well, then apply thin film to affected area(s) using fingers. Wash hands after applying product.
- Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.
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Acne, Rosacea, Seborrheic Dermatitis
