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Sertaconazole Nitrate

Pronunciation: SIR-tah-KAHN-uh-zole NYE-trate
Class: Antifungal agent

Trade Names

Ertaczo
- Cream 2%

Pharmacology

Alters permeability of fungal cell membrane, leading to cell death.

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Indications and Usage

Topical treatment of interdigital tinea pedis caused by Trichophyton rubrum , Trichophyton mentagrophytes , and Epidermophyton floccosum in immunocompetent patients.

Contraindications

Sensitivity to imidazoles or any component of the product.

Dosage and Administration

Adults and children 12 yr of age and older

Topical Apply twice daily for 4 wk, applying a sufficient amount to cover affected areas between the toes and immediately surrounding skin. Review the diagnosis if no improvement is noted 2 wk after starting treatment.

Storage/Stability

Store cream at controlled room temperature (59° to 86°F). Keep tube tightly capped.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Contact dermatitis, dry skin, burning skin, application-site reaction, skin tenderness (2%).

Precautions

Monitor

Assess and document skin condition before initial application and periodically throughout treatment.


Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established in children younger than 12 yr of age.

Diagnosis

Should be confirmed by direct microscopic examination of infected superficial epidermal tissue or by culture on appropriate medium.

Patient Information

  • Advise patient to try to keep affected areas as dry as possible because moist skin favors growth of fungi.
  • Advise patient to carefully dry between the toes after showering or bathing, apply drying and dusting powders as necessary, and change socks frequently.
  • Teach patient or caregiver proper technique for applying cream: wash hands; apply sufficient cream to cover affected areas between the toes and the immediately surrounding healthy skin and gently massage into skin. Wash hands after applying cream. Caution patient not to cover with occlusive dressing unless advised by health care provider.
  • Advise patient to apply cream to affected areas twice daily as directed by health care provider.
  • Caution patient to avoid contact with eyes, nose, mouth, and other mucus membranes. Advise patient that if cream does come into contact with the eyes, to wash eyes with large amounts of cool water and contact health care provider if eye irritation occurs.
  • Advise patient that symptoms should begin to improve fairly soon after starting treatment, but to continue applying cream as directed for full treatment period to prevent recurrence of infection.
  • Advise patient to notify health care provider if condition does not improve, worsens, or if application-site reactions (eg, irritation, burning, stinging, redness, itching, blistering, swelling, oozing) develop and are bothersome.

Copyright © 2009 Wolters Kluwer Health.

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