Selenium (as selenious acid)

Trade Names:
Sele-Pak
- Injection 40 mcg/mL (as 65.4 mcg selenious acid)

Trade Names:
Selepen
- Injection 40 mcg/mL (as 65.4 mcg selenious acid)

Pharmacology

Part of glutathione peroxidase, which protects cell components from oxidative damage caused by peroxidases produced in cellular metabolism.

Pharmacokinetics

Elimination

Primarily by the kidney but endogenous losses occur through the feces.

Indications and Usage

Use as a supplement to IV total parenteral nutrition (TPN) solutions to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Contraindications

Do not give undiluted by direct IV injection.

Dosage and Administration

TPN Additive Metabolically stable patients: 20 to 40 mcg/day. In selenium deficiency states resulting from long-term TPN support: 100 mcg/day for 24 to 31 days.

TPN Additive 3 mcg/kg/day.

Storage/Stability

Store vials at controlled room temperature (59° to 86°F).

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Unlikely to occur at recommended dosage level.

Precautions

Pregnancy

Category C .

Renal Function

Supplement dosage may be adjusted, reduced, or omitted.

Benzyl alcohol

Contains benzyl alcohol in multidoses preparation.

GI malfunction

Dose may be adjusted, reduced, or omitted.

Overdosage

Symptoms

Death (preceded by coma) with histopathological changes, including fulminating peripheral vascular collapse, internal vascular congestion, edematous lungs, brick red–color gastric mucosa

Hair loss, weakened nails, dermatitis, dental defects, GI disorders, nervousness, mental depression, metallic taste, vomiting, garlic odor of breath and sweat

Patient Information

• Advise patient, family, or caregiver that medication will be added to TPN solution.
• Advise patient to report pain, redness, warmth, or swelling of TPN access site.

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