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Learn how to prepare for Severe Allergy Attacks.

Pyrilamine Tannate

Pronunciation: pir-IL-a-meen TAN-nate
Class: Antihistamine

Trade Names

- Suspension 12 mg per 5 mL


Suppresses symptoms of allergic rhinitis.

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Indications and Usage

Symptomatic relief of acute rhinitis and nasal congestion associated with the common cold, seasonal and perennial allergic rhinitis, sinusitis, and other respiratory tract conditions.


Newborns; breast-feeding women; hypersensitivity.

Dosage and Administration

Adults and Children 12 yr of age and older

PO 12 to 24 mg (5 to 10 mL) every 12 h (max, 48 mg per 24 h).

Children 6 to 12 yr of age

PO 12 mg (5 mL) every 12 h (max, 24 mg per 24 h).

Children 2 to 6 yr of age

PO 6 mg (2.5 mL) every 12 h (max, 12 mg per 24 h).

General Advice

  • Shake well before using.


Store at 59° to 86°F. Protect from light and freezing.

Drug Interactions

Alcohol, CNS depressants (eg, hypnotics, sedatives, tranquilizers)

May have additive CNS effects (eg, increased drowsiness).

Antihypertensives (eg, mecamylamine, methyldopa, reserpine, veratrum alkaloids)

Antihypertensive effects may be reduced.

Beta-blockers (eg, propranolol)

Effects of pyrilamine may be increased.


Do not use with or within 14 days after stopping MAOI therapy.


Increased risk of mild sedation or stimulation.

Laboratory Test Interactions

None well documented.

Adverse Reactions


CNS depression, drowsiness, sedation.


Dryness of mucous membranes.


GI effects.


Urinary retention in patients with prostatic hypertrophy.



Monitor renal function in elderly patients.


Category C .




Safety and efficacy not established in children younger than 2 yr of age.


Use with caution because of increased likelihood of decreased renal function, increasing the risk of dizziness, hypertension, and sedation.

Renal Function

Risk of toxicity may be increased in patients with renal function impairment.

Special Risk Patients

Use with caution in patients with CV disease, diabetes, hypertension, hyperthyroidism, narrow-angle glaucoma, or prostatic hypertrophy.

Paradoxical effect

May cause excitation, particularly in children.


Contains phenylalanine.



Atropine-like signs and symptoms, CNS stimulation or depression. CNS depression, convulsions, death, diminished mental alertness, excitation, hallucinations, or respiratory or cardiac arrest in infants and children.

Patient Information

  • Caution patients to avoid drinking alcoholic beverages and using other depressants.
  • Advise patients that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness or coordination.

Copyright © 2009 Wolters Kluwer Health.