Polyethylene Glycol-Electrolyte Solution
( PEG-ES ) Pronouncation: (poli-eth-uh-leen gli-cawl)Class: Bowel evacuant
Trade Names:
CoLyte
- Powder for oral solution 1 gal: 227.1 g PEG 3350, 21.5 g sodium sulfate, 6.36 g sodium bicarb, 5.53 g NaCl, 2,82 g KCl
- Powder for oral solution 4L: 240 g PEG 3350, 22.72 g sodium sulfate, 6.72 g sodium bicab, 5.84 g NaCl, 2.98 g KCl
Trade Names:
GoLYTELY
- Powder for oral suspension 236 g PEG 3350, 22.74 g sodium sulfate, 6.74 g sodium bicarb, 5.86 g NaCl, 2.97 g KCl
- Powder for oral suspension 227.1 g PEG 3350, 21.5 sodium sulfate, 6.36 g sodium bicarb, 5.53 g NaCl, 2.82 g KCl
Trade Names:
NuLYTELY
- Powder for reconstitution 420 g PEG 3350, 5.72 g sodium bicarb, 11.2 g NaCl, 1.48 g KCl
Trade Names:
OCL
- Oral solution 146 mg NaCl, 168 mg sodium bicarb, 1.29 g sodium sulfate decahydrate, 75 mg KCl, 6 g PEG 3350, 30 mg polysorbate 80/100 mL
Pharmacology
Feedback for Polyethylene Glycol-Electrolyte Solution (PEG-ES)
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Induces diarrhea, which rapidly cleanses bowel, usually within 4 h.
Pharmacokinetics
Absorption
Negligible.
Onset
30 to 60 min.
Indications and Usage
Bowel cleansing prior to GI examination.
Unlabeled Uses
Management of acute iron overdose in children.
Contraindications
GI obstruction; gastric retention; bowel perforation; toxic colitis; toxic megacolon or ileus.
Dosage and Administration
AdultsPO / Nasogastric 4 L prior to GI examination. Give orally as 240 mL q 10 min or via NG tube as 1.2 to 1.8 L/h until 4 L are consumed or until rectal effluent is clear. Via nasogastric (NG) tube, use rate of 1.2 to 1.8 L/h.
General Advice
- May be given via NG tube for patients unable or unwilling to drink solution.
- Reconstitute powder for oral solution with tap water and shake container until powder is dissolved.
- Do not add flavorings or additional ingredients to solution before use. Chilling solution before administration improves palatability.
Storage/Stability
Refrigerate reconstituted solution. Use within 48 h.
Drug Interactions
Oral medication given within 1 h of starting therapyMedication may be flushed from GI tract and not absorbed.
Laboratory Test Interactions
None well documented.
Adverse Reactions
Dermatologic
Urticaria; dermatitis.
EENT
Rhinorrhea.
GI
Nausea; abdominal fullness; bloating; abdominal cramps; vomiting; anal irritation.
Precautions
Pregnancy
Category C .
Children
Safety and efficacy not established.
Regurgitation/Aspiration
Use with caution in patients with impaired gag reflex.
Severe ulcerative colitis
Use with caution. If GI obstruction or perforation is suspected, rule out these contraindications before administration.
Overdosage
Symptoms
Diarrhea, bloating, abdominal pain.
Patient Information
- Explain that solution is given to cleanse bowel as preparation for GI examination.
- Explain that if discomfort becomes intolerable, patient should stop drinking solution temporarily or allow longer intervals between drink portions.
- Instruct patient not to eat or drink anything for 3 to 4 h before ingestion and explain that only clear liquids are allowed after ingestion of solution.
- Tell patient to continue drinking solution until watery stool is clear and free of solid material.
- Instruct patient to report the following symptoms to health care provider: severe bloating, distention, or abdominal pain.
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Constipation -- Chronic, Bowel Preparation, Gastrointestinal Decontamination










