Polyethylene Glycol-Electrolyte Solution

( PEG-ES )

Pronunciation: poli-eth-uh-leen gli-cawl
Class: Bowel evacuant

Trade Names

CoLyte
- Powder for oral solution 1 gal: 227.1 g PEG 3350, 21.5 g sodium sulfate, 6.36 g sodium bicarbonate, 5.53 g sodium chloride, 2,82 g potassium chloride
- Powder for oral solution 4L: 240 g PEG 3350, 22.72 g sodium sulfate, 6.72 g sodium bicarbonate, 5.84 g sodium chloride, 2.98 g potassium chloride

GaviLyte-C
- Powder for oral solution 240 g PEG 3350, 22.72 sodium sulfate, 6.72 g sodium bicarbonate, 5.84 g sodium chloride, 2.97 g potassium chloride

GaviLyte-G
- Powder for oral solution 236 g PEG 3350, 22.74 g sodium sulfate, 6.74 g sodium bicarbonate, 5.86 g sodium chloride, 2.97 g potassium chloride

GaviLyte-N
- Powder for oral solution 420 g PEG 3350, 5.72 g sodium bicarbonate, 11.2 g sodium chloride, 1.48 g potassium chloride

GoLYTELY
- Powder for oral suspension 236 g PEG 3350, 22.74 g sodium sulfate, 6.74 g sodium bicarbonate, 5.86 g sodium chloride, 2.97 g potassium chloride
- Powder for oral suspension 227.1 g PEG 3350, 21.5 sodium sulfate, 6.36 g sodium bicarbonate, 5.53 g sodium chloride, 2.82 g potassium chloride

MoviPrep
- Powder for oral solution 100 g PEG 3350, 7.5 g sodium sulfate, 2.691 g sodium chloride, 1.015 potassium chloride

NuLYTELY
- Powder for oral solution 420 g PEG 3350, 5.72 g sodium bicarbonate, 11.2 g sodium chloride, 1.48 g potassium chloride

TriLyte
- Powder for oral solution 420 g PEG 3350, 5.72 g sodium bicarbonate, 11.2 g sodium chloride, 1.48 g potassium chloride

Klean-Prep (Canada)
PegLyte (Canada)

Pharmacology

Induces diarrhea, which rapidly cleanses bowel, usually within 4 h.

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Pharmacokinetics

Absorption

Negligible.

Onset

30 to 60 min.

Indications and Usage

Bowel cleansing prior to GI examination.

Unlabeled Uses

Management of acute iron overdose in children.

Contraindications

GI obstruction; gastric retention; bowel perforation; toxic colitis; toxic megacolon or ileus.

Dosage and Administration

Adults

PO / Nasogastric 4 L prior to GI examination. Give orally as 240 mL q 10 min or via NG tube as 1.2 to 1.8 L/h until 4 L are consumed or until rectal effluent is clear. Via nasogastric (NG) tube, use rate of 1.2 to 1.8 L/h.

General Advice

  • May be given via NG tube for patients unable or unwilling to drink solution.
  • Reconstitute powder for oral solution with tap water and shake container until powder is dissolved.
  • Do not add flavorings or additional ingredients to solution before use. Chilling solution before administration improves palatability.

Storage/Stability

Refrigerate reconstituted solution. Use within 48 h.

Drug Interactions

Oral medication given within 1 h of starting therapy

Medication may be flushed from GI tract and not absorbed.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Urticaria; dermatitis.

EENT

Rhinorrhea.

GI

Nausea; abdominal fullness; bloating; abdominal cramps; vomiting; anal irritation.

Precautions

Pregnancy

Category C .

Children

Safety and efficacy not established.

Regurgitation/Aspiration

Use with caution in patients with impaired gag reflex.

Severe ulcerative colitis

Use with caution. If GI obstruction or perforation is suspected, rule out these contraindications before administration.

Overdosage

Symptoms

Diarrhea, bloating, abdominal pain.

Patient Information

  • Explain that solution is given to cleanse bowel as preparation for GI examination.
  • Explain that if discomfort becomes intolerable, patient should stop drinking solution temporarily or allow longer intervals between drink portions.
  • Instruct patient not to eat or drink anything for 3 to 4 h before ingestion and explain that only clear liquids are allowed after ingestion of solution.
  • Tell patient to continue drinking solution until watery stool is clear and free of solid material.
  • Instruct patient to report the following symptoms to health care provider: severe bloating, distention, or abdominal pain.

Copyright © 2009 Wolters Kluwer Health.

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