Class: Monoclonal antibody
- Injection, solution 100 mg/mL
Neutralizing and fusion-inhibitory activity against respiratory syncytial virus (RSV), inhibiting RSV replication.
The half-life is 20 days in children younger than 24 mo of age.
Indications and Usage
Prevention of serious lower respiratory tract disease caused by RSV in children at high risk of RSV disease.
Dosage and AdministrationChildren
IM 15 mg/kg monthly through the RSV season. Give doses of more than 1 mL in divided doses.
- For IM administration only. Not for intra-arterial, intradermal, subcutaneous, or IV administration.
- Preferably administer in anterolateral aspect of thigh. Avoid gluteal injections because of risk of damage to sciatic nerve.
- Administer first dose prior to commencement of RSV season.
- Administer immediately after dose is withdrawn from the vial.
- Do not vigorously agitate the vial.
Store at 36° to 46°F in original containers. Do not freeze. Discard any unused portion.
None well documented.
Laboratory Test Interactions
None well documented.
Otitis media (36%); rhinitis (27%).
Hernia (4%); diarrhea; vomiting; gastroenteritis.
Increased AST (3%).
Upper respiratory tract infection (51%); cough; wheezing.
Fever (27%); anaphylaxis, injection-site reaction, severe acute hypersensitivity (including dyspnea, cyanosis, respiratory failure, urticaria, pruritus, angioedema, hypotonia, and unresponsiveness); severe thrombocytopenia (postmarketing).
Monitor patient for signs and symptoms of allergic reaction.
Category C .
Severe hypersensitivity reactions on initial exposure and reexposure to palivizumab rarely have been reported. Be prepared to treat appropriately.
Not indicated for adult use.
Palivizumab serum levels are decreased after cardiopulmonary bypass. Administer a dose of palivizumab as soon as possible after the cardiopulmonary bypass procedure, even if sooner than a month from the previous dose. Thereafter, doses should be administered monthly.
Administer with caution to patients with thrombocytopenia or any coagulation disorder caused by risk of bleeding at IM injection site.
No data available.
- Advise family or caregiver that medication will be prepared and administered by a health care provider in a health care setting.
- Educate family or caregiver of importance of monthly injection in helping to prevent RSV infection during the RSV season.
- Advise family or caregiver to report any of the following to health care provider: injection-site reactions; fever or other signs of infection; sore throat; rash; itching or hives; swelling of the face, lips, eyes, or tongue; diarrhea; wheezing; shortness of breath; difficulty breathing.
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