Oxycodone Hydrochloride / Aspirin
Pronunciation: OX-ee-KOE-dohn HIGH-droe-KLOR-ide/ASS-pihr-in
Class: Opioid analgesic combination
- Tablets 4.5 mg oxycodone hydrochloride/ 0.38 mg oxycodone terephthalate/325 mg aspirin
Relieves pain by stimulating opiate receptors in CNSAspirin
Inhibits prostaglandin synthesis, resulting in analgesia, anti-inflammatory activity, and inhibition of platelet aggregation.
Indications and Usage
For the relief of moderate to moderately severe pain.
Hypersensitivity to any component of the product.
Dosage and AdministrationAdults
PO Usual dose is 1 tablet every 6 h as needed for pain (max, 12 tablets [4 g aspirin] every 24 h).
Store at controlled room temperature (59° to 86°F).
Drug InteractionsAnticoagulants (eg, warfarin)
Effects of anticoagulants may be enhanced by aspirin, increasing the risk of bleeding.CNS depressants (eg, alcohol, phenobarbital), general anesthetics, opioid analgesics, phenothiazines, sedative-hypnotics, tranquilizers
Effects may be additive.Uricosuric agents (eg, probenecid)
Effects may be inhibited by aspirin.
Laboratory Test Interactions
None well documented.
Lightheadedness; dizziness; sedation; euphoria; dysphoria.
Nausea; vomiting; constipation.
Safety of use has not been established.
Safety and efficacy not established. Reye syndrome has been associated with aspirin administration to children (including teenagers) with acute febrile illness.
Special Risk Patients
Use with caution in the elderly or debilitated and patients with severe hepatic or renal function impairment, peptic ulcers, hypothyroidism, Addison disease, and prostatic hypertrophy or urethral stricture.
Acute abdominal conditions
Diagnosis or clinical course may be obscured.
Mental and physical abilities may be impaired.
Oxycodone has abuse potential.
Head injury and increased intracranial pressure
Cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury.
Use with caution in the presence of peptic ulcer.
Respiratory depression, extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, bradycardia, hypotension, apnea, circulatory collapse, cardiac arrest, death.
- Advise patient to take 1 tablet every 6 h or as prescribed if needed for pain but to not take more than 12 tablets in 24 h.
- Advise patient to take without regard to meals but to take with food if GI upset occurs.
- Instruct patient to avoid alcoholic beverages and other depressants while taking this medication.
- Advise patient that drug may impair judgment, thinking, or motor skills or cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
- Advise patient to stop taking the drug and notify health care provider if any of the following occur: allergic reaction, unusual bleeding or bruising, shortness of breath, black or tarry stools, vomiting of blood or coffee ground-like material, excessive sedation.
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