Oxycodone / Acetaminophen
Pronouncation: (OX-ee-KOE-dohn/ass-cet-ah-MEE-noe-fen)Class: Opioid analgesic combination
Trade Names:
Percocet
- Tablets 5 mg oxycodone hydrochloride/325 mg acetaminophen
- Tablets 7.5 mg oxycodone hydrochloride/500 mg acetaminophen
- Tablets 10 mg oxycodone hydrochloride/650 mg acetaminophen
Trade Names:
Roxicet
- Tablets 5 mg oxycodone hydrochloride/325 mg acetaminophen
- Solution, oral 5 mg oxycodone hydrochloride/325 mg acetaminophen
Trade Names:
Roxicet 5/500
- Caplets 5 mg oxycodone/500 mg acetaminophen
Trade Names:
Roxilox
- Capsules 5 mg oxycodone hydrochloride/500 mg acetaminophen
Trade Names:
Tylox
- Capsules 5 mg oxycodone hydrochloride/500 mg acetaminophen
ratio-Oxycocet (Canada)
Pharmacology
Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.
Indications and Usage
Relief of moderate to moderately severe pain.
Contraindications
Hypersensitivity to acetaminophen, oxycodone, or similar compounds.
Dosage and Administration
AdultsPO 5 mg (1 tablet, caplet, or teaspoonful) every 6 h as needed.
Storage/Stability
Store at room temperature (59° to 86°F).
Drug Interactions
AnestheticsAdditive CNS depression.
Carbamazepine, hydantoins, sulfinpyrazoneIncreased risk of hepatotoxicity.
CNS depressants (eg, barbiturates, tricyclic antidepressants, phenothiazines, sedatives, hypnotics, alcohol, other narcotics)Additive CNS depression.
Laboratory Test Interactions
With Chemstrip bG , Dextrostix , and Visidex II home blood glucose systems, may cause false decrease in mean glucose values.
Adverse Reactions
Cardiovascular
Hypotension; bradycardia; tachycardia.
CNS
Lightheadedness; dizziness; weakness; fatigue; sedation; euphoria; dysphoria; nervousness; headache; confusion.
Dermatologic
Pruritus; rash.
GI
Nausea; vomiting; constipation; abdominal pain; anorexia; biliary spasm; dry mouth.
Genitourinary
Urinary retention or hesitancy.
Respiratory
Dyspnea; respiratory depression.
Miscellaneous
Malaise; tolerance; psychological and physical dependence with chronic use.
Precautions
Pregnancy
Category C .
Lactation
Undetermined.
Children
Safety and efficacy not established.
Hepatic Function
Chronic alcoholics should limit acetaminophen intake to less than 2 g/day.
Special Risk Patients
Use with caution in elderly, debilitated patients and those with hepatic or kidney failure or conditions accompanied by hypoxia or hypercapnia; monitor carefully to avoid decrease in pulmonary ventilation. Also use cautiously in patients sensitive to CNS depressants, postoperatively and in patients with pulmonary disease.
Sulfite Sensitivity
Use with caution in patients known to be sensitive, as some products contain bisulfites.
Acute abdominal conditions
Diagnosis may be obscured; use with caution.
Dependence
Can produce drug dependence; has abuse potential.
Head injury
Respiratory depression and elevation of CSF pressure may be exacerbated.
Overdosage
Symptoms
Miosis, respiratory depression, CNS depression (somnolence progressing to stupor or coma), hepatic damage, circulatory collapse, cardiopulmonary arrest, death.
Patient Information
- Instruct patient to take medication before pain becomes severe for greatest effectiveness.
- Teach patient methods to prevent constipation.
- Instruct patient to make position changes slowly if lightheadedness or sedation occurs.
- Advise patient to avoid intake of alcoholic beverages or products containing alcohol while using this medication.
- Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
- Caution patient that physical dependency and withdrawal symptoms may occur following discontinuation of long-term therapy.
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