A-Z Drug Facts > Orphenadrine Citrate/Aspirin/Caffeine

Orphenadrine Citrate / Aspirin / Caffeine

Pronouncation: (ore-FEN-uh-dreen SIH-trate/ASS-pihr-in/kaff-EEN)
Class: Skeletal muscle relaxant

Trade Names:
Norgesic
- Tablets 25 mg orphenadrine citrate per 385 mg aspirin per 30 mg caffeine

Trade Names:
Norgesic Forte
- Tablets 50 mg orphenadrine citrate per 770 mg aspirin per 60 mg caffeine

Pharmacology

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Orphenadrine

May be related to analgesic properties.

Aspirin

Inhibits prostaglandin synthesis, resulting in analgesia, anti-inflammatory activity, and inhibition of platelet aggregation.

Caffeine

Is thought to produce constriction of cerebral blood vessels.

Indications and Usage

Symptomatic relief of mild to moderate pain of acute musculoskeletal disorders; adjunct to rest, physical therapy, and other measures for the relief of discomfort with acute painful musculoskeletal conditions.

Contraindications

Patients with glaucoma, pyloric or duodenal obstruction, achalasia (eg, failure of visceral openings or sphincter muscle to relax), prostatic hypertrophy or obstructions at the bladder neck, myasthenia gravis; hypersensitivity to any component of the product.

Dosage and Administration

Adults

PO Norgesic 1 to 2 tablets 3 to 4 times daily; Norgesic Forte ½ to 1 tablet 3 to 4 times daily.

Storage/Stability

Store below 86°F. Protect from moisture.

Drug Interactions

Anticoagulants (eg, warfarin)

Effects of anticoagulants may be enhanced by aspirin, increasing the risk of bleeding.

Uricosuric agents (probenecid)

Effects may be inhibited by aspirin.

Adverse Reactions

Cardiovascular

Tachycardia; palpitation.

CNS

Weakness; confusion; excitation; hallucinations; headache; lightheadedness; dizziness; syncope.

Dermatologic

Urticaria and other dermatoses.

EENT

Blurred vision; dilation of the pupil; increased intraocular tension; drowsiness.

GI

Dry mouth; nausea; vomiting; hemorrhage.

Genitourinary

Urinary hesitancy or retention; constipation.

Precautions

Pregnancy

Safety and efficacy not established.

Lactation

Undetermined.

Children

Safety and efficacy not established.

Reye syndrome

Has been associated with aspirin administration to children (including teenagers) with acute febrile illness.

Peptic ulcers

Use with extreme caution.

Patient Information

• Advise patient to take prescribed dose 3 to 4 times daily if needed for muscle pain, muscle spasm, or limited mobility.
• Advise patient to take without regard to meals but to take with food if GI upset occurs.
• Instruct patient to avoid alcoholic beverages and other depressants while taking this medication.
• Advise patient that drug may cause drowsiness, dizziness, or blurred vision and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
• Advise patient to stop taking the drug and notify health care provider if any of the following occur: allergic reaction, unusual bleeding or bruising, shortness of breath, black or tarry stools, vomiting of blood or coffee ground-like material.

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