Nystatin / Triamcinolone Acetonide

Pronunciation: nye-STAT-in/TRY-am-SIN-oh-lone ah-SEE-toe-nide
Class: Corticosteroid, Antifungal combination

Trade Names

Nystatin/Triamcinolone Acetonide
- Cream 100,000 units/g nystatin, 0.1% triamcinolone
- Ointment 100,000 units/g nystatin, 0.1% triamcinolone

Pharmacology

The antifungal binds to fungal cell membrane, changing membrane permeability and allowing leakage of intracellular components; the corticosteroid adds anti-inflammatory, antipruritic, and vasoconstrictive action.

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Indications and Usage

Cutaneous candidiasis.

Contraindications

Standard considerations.

Dosage and Administration

Adults and Children

Topical Apply as a thin film to affected area(s) twice daily.

General Advice

  • For topical use only. Not for ophthalmic or otic use.

Storage/Stability

Store at controlled room temperature (59° to 86°F).

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Acneiform eruptions; burning; itching; irritation; dryness; folliculitis; hypertrichosis; hypopigmentation; perioral dermatitis; allergic contact dermatitis; maceration; secondary infection; skin atrophy; striae; miliaria.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Greater risk of HPA axis suppression, Cushing syndrome, intracranial hypertension.

Risk of HPA axis suppression, Cushing syndrome, hyperglycemia, glycosuria

Conditions that augment cutaneous absorption include use of large body surface area, prolonged use, and occlusive dressings.

Patient Information

  • Review prescribed dosing schedule with patient or caregiver.
  • Remind patient or caregiver that medicine is not to be used in the eye or ear.
  • Teach patient or caregiver proper technique for applying medicine: wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after application.
  • Caution patient or caregiver not to occlude treated skin area with bandage, cover, or wrap.
  • Advise patient or caregiver to contact health care provider if local redness or swelling develops, or if skin lesions do not improve or worsen.

Copyright © 2009 Wolters Kluwer Health.

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