Pronunciation: MILL-rih-nohn LAK-tate
Class: Inotropic agent
- Injection, premixed 200 mcg/mL in dextrose 5% injection
Has direct arterial vasodilator activity and positive inotropic effect; increases myocardial contractility.
Steady state is reached after approximately 6 to 12 h of infusion of 0.5 mcg/kg/min. Therapeutic range is 100 to 300 ng/mL.
Approximately 70% is protein bound and Vd is 0.38 L/kg.
Metabolite is 0-glucuronide.
Primary route of excretion is via urine. Major urinary excretions of orally administered milrinone is 83% and 12% for 0-glucuronide metabolite. Mean t ½ is 2.3 h and Cl is 0.13 L/kg/h.
Duration depends on patient's responsiveness (approximately 5 days).
Indications and Usage
Short-term treatment of CHF.
Dosage and AdministrationAdults Loading dose
IV 50 mcg/kg over 10 min; adjust infusion rate according to hemodynamic and clinical response.
Store at room temperature (59° to 86°F) and protect from light.
None well documented.
Precipitate forms if furosemide is injected into same IV line as milrinone; do not administer both in same IV line.
Laboratory Test Interactions
None well documented.
Ventricular arrhythmia (eg, ventricular ectopic activity, nonsustained ventricular tachycardia, sustained ventricular tachycardia, ventricular fibrillation); supraventricular arrhythmia; hypotension; angina.
Category C .
Safety and efficacy not established.
Use drug with caution; monitor renal function. Dosage reduction, based on CrCl, may be needed.
Do not use in patients with severe obstructive aortic or pulmonic valvular disease; may exacerbate hypertrophic subaortic stenosis; may cause supraventricular and ventricular arrhythmias; may shorten atrioventricular node conduction.
- Inform patient that treatment with this drug usually does not exceed 5 days.
- Instruct patient to report the following symptoms to health care provider: headache or tremors.
Copyright © 2009 Wolters Kluwer Health.
More about milrinone
- Milrinone Lactate (AHFS Monograph)
- Milrinone (FDA)
- Milrinone Dextrose (FDA)
- Milrinone Injection (FDA)
- Milrinone Lactate in Dextrose Injection (FDA)
- Other brands: Primacor