Methamphetamine Hydrochloride
( Desoxyephedrine Hydrochloride ) Pronouncation: (meth-am-FET-uh-meen HIGH-droe-KLOR-ide)Class: Amphetamine
Trade Names:
Desoxyn
- Tablets 5 mg
Pharmacology
Feedback for Methamphetamine Hydrochloride (Desoxyephedrine Hydrochloride)
Compare with other drugs.
  |
Activates noradrenergic neurons causing CNS and respiratory stimulation; stimulates the satiety center in the brain, causing appetite suppression.
Pharmacokinetics
Absorption
Methamphetamine is rapidly absorbed from the GI tract.
Metabolism
Primary site for metabolism is the liver, by aromatic hydroxylation, N-dealkylation, and deamination. There are at least 7 metabolites.
Elimination
Primary route for excretion is urine (dependent on pH) and the t ½ is 4 to 5 h.
Indications and Usage
Treatment of attention deficit disorder in children; short-term exogenous obesity adjunct.
Contraindications
Advanced arteriosclerosis; symptomatic CV disease; moderate to severe hypertension; hyperthyroidism; hypersensitivity to sympathomimetic amines; glaucoma; agitated states; history of drug abuse. Drug should not be used concomitantly with or within 14 days of MAOI use.
Dosage and Administration
Attention Deficit DisorderChildren
PO 5 mg 1 to 2 times/day; may be increased weekly by 5 mg to max of 20 to 25 mg/day in divided doses.
Exogenous ObesityAdults and Children (older than 12 yr of age)
PO 5 mg 1 to 3 times/day 30 min before meals. Not to be used beyond a few weeks.
Storage/Stability
Store in tightly closed container at room temperature (59° to 86°F).
Drug Interactions
GuanethidineAmphetamines may decrease effectiveness.
MAOIs, furazolidoneHypertensive crisis and intracranial hemorrhage may occur.
Tricyclic AntidepressantsDecreased amphetamine effect.
Urinary acidifiersDecreased amphetamine levels.
Urinary alkalinizersIncreased amphetamine levels.
Laboratory Test Interactions
Plasma and urinary steroid levels may be altered.
Adverse Reactions
Cardiovascular
Palpitations; tachycardia; hypertension; arrhythmias.
CNS
Hyperactivity; dizziness; insomnia; euphoria; restlessness; tremors; headache.
Dermatologic
Urticaria.
GI
Dry mouth; unpleasant taste; diarrhea; constipation; anorexia.
Genitourinary
Impotence.
Precautions
WarningsHigh abuse/diversion potential. Drug dependence may develop with chronic use. Avoid long periods of use. Prescribe and dispense sparingly because of high diversion potential. |
Pregnancy
Category C .
Lactation
Excreted in breast milk.
Children
Not recommended as anorectic agent in children less than 12 yr of age.
Tartrazine Sensitivity
Some products contain tartrazine, which may cause allergic reactions in susceptible individuals.
Tolerance
Tolerance may occur; do not exceed recommended dose.
Overdosage
Symptoms
Restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic attack, hyperpyrexia.
Patient Information
- Instruct patient to take medication exactly as prescribed and not to increase dosage unless advised by health care provider.
- Advise patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
- Instruct patient to report excessive dryness of mouth, constipation, or prolonged insomnia as dosage may need to be adjusted.
- Tell patient to avoid caffeine, which increases drug effect.
- Advise patient that drug may cause dizziness and to use caution while driving or performing other tasks requiring mental alertness or coordination.
- Tell parents to report decreased appetite to pediatrician.
| Link to this page |  |
Printable Version |  |
Email Page |  |
Add to my drug list |
Attention Deficit Hyperactivity Disorder (ADHD), Obesity
User Reviews:
2 comment(s) about Methamphetamine Hydrochloride (Desoxyephedrine Hydrochloride)
