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Kunecatechins

Pronunciation: koo-nee-KAT-eh-chins
Class: Catechin

Trade Names

Veregen
- Ointment 15%, dispensed in 15 g tube

Pharmacology

The mechanism of action is unknown; however, based on in vitro data, kunecatechins has antioxidative activity.

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Indications and Usage

Topical treatment of external genital and perianal warts in immunocompetent patients 18 yr of age and older.

Contraindications

Standard considerations.

Dosage and Administration

Adults

Topical Apply 3 times daily to all external genital and perianal warts.

General Advice

  • Wash hands before and after application of the ointment.
  • Apply about a 0.5 cm strand of ointment to each wart using finger(s), dabbing it on to ensure complete coverage and leaving a thin layer of ointment on warts.
  • It is not necessary to wash ointment from treated area prior to the next application.
  • Continue treatment until complete clearance of all warts, but no longer than 16 wk.
  • Although local skin reactions at treatment sites are frequent, treatment should be continued when severity of the local skin reaction is acceptable.

Storage/Stability

Refrigerate at 36° to 46°F. After dispensing, store refrigerated or up to 77°F. Do not freeze.

Drug Interactions

Drug interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Local

Erythema (70%); pruritus (69%); burning (67%); pain/discomfort (56%); erosion/ulceration (49%); edema (45%); induration (35%); vesicular rash (20%); desquamation (5%); discharge, phimosis in uncircumcised males, regional lymphadenitis (3%); bleeding (2%); irritation, rash, scar (1%).

Miscellaneous

Hypersensitivity (2%).

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Immunosuppressed patients

Safety and efficacy not established.

Open wounds

Avoid use.

Sun/Ultraviolet (UV) light

Avoid exposure of the genital and perianal area to sun/UV light; kunecatechins has not been tested under these circumstances.

Viral disease

Kunecatechins has not been evaluated for treatment of urethral, intravaginal, cervical, rectal, or intraanal human papilloma viral disease and should not be used for these conditions.

Overdosage

Symptoms

Has not been reported.

Patient Information

  • Obtain patient history, including drug history and any known allergies.
  • Use only as directed by health care provider.
  • Inform patient that product is for external use only and to avoid contact with eye or application into vagina or anus.
  • Inform patient that local skin reactions, such as erythema, erosion, edema, itching, and burning at the site of application, are common. However, severe skin reactions can occur and should be promptly reported to the health care provider.
  • Instruct patient that if severe local skin reactions occur, to remove the ointment by washing treated area with mild soap and water; hold further applications.
  • Advise patient that it is not necessary to wash off ointment prior to next application but when treatment area is washed or bathed, reapply ointment afterwards.
  • Advise patient to avoid sexual contact while ointment is on the skin, or to wash off ointment prior to the activity.
  • Inform patient that the product may weaken condoms and vaginal diaphragms; their use with kunecatechins is not recommended.
  • Instruct female patients using tampons to insert the tampon prior to applying the ointment. Caution patient to avoid accidental application of ointment into vagina if tampon is changed.
  • Caution patient that product may stain clothing and bedding.
  • Inform patient that product is not a cure and new warts might develop during or after therapy. New warts developing during the 16-wk treatment period should be treated with the product.
  • Advise patients using ointment to avoid exposure of genital and perianal area to sun/UV light.
  • Instruct patient not to bandage or otherwise cover or wrap treated area.
  • Advise uncircumcised males treating warts under the foreskin to retract the foreskin and clean the area daily.

Copyright © 2009 Wolters Kluwer Health.

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