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Isoxsuprine Hydrochloride

Pronouncation: (eye-SOX-you-preen HIGH-droe-KLOR-ide)
Class: Peripheral vasodilator

Trade Names:
Vasodilan
- Tablets 10 mg
- Tablets 20 mg

Trade Names:
Voxsuprine
- Tablets 10 mg
- Tablets 20 mg

Pharmacology

Stimulates skeletal beta receptors to produce vasodilation; stimulates cardiac function (increased contractility, heart rate, and cardiac output) and relaxes uterus. At higher doses, inhibits platelet aggregation and decreases blood viscosity.

Pharmacokinetics

Absorption

Well absorbed from the GI tract.

Metabolism

Partially conjugated in the blood.

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Elimination

The t 1/2 is approximately 1.25 h. Primarily excreted in the urine.

Onset

1 h (oral); 10 min (IV).

Special Populations

Neonates

The t 1/2 is 1.5 to 3 h (near term) and 6 to 8 h (for less mature).

Indications and Usage

Possibly effective for treatment of cerebral vascular insufficiency, peripheral vascular disease caused by arteriosclerosis obliterans, thromboangiitis obliterans, Raynaud's disease.

Unlabeled Uses

Treatment of dysmenorrhea, premature labor.

Contraindications

Arterial bleeding; use during immediate postpartum period.

Dosage and Administration

Adults

PO 10 to 20 mg 3 or 4 times daily.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Hypotension; tachycardia; chest pain.

CNS

Dizziness; weakness.

Dermatologic

Severe rash.

GI

Nausea; vomiting; abdominal distress.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Patient Information

  • Instruct patient to report the following symptoms to health care provider: Fast heartbeat, chest pain, pounding in chest, severe rash, flushing, weakness, nausea, vomiting, stomach pain.
  • Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
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