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Flavoxate

Pronunciation: (flay-voke-sate)
Class: Urinary tract antispasmodic, Alkalinizer

Trade Names:
Urispas
- Tablets 100 mg

Apo-Flavoxate (Canada)

Pharmacology

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Counteracts smooth muscle spasms of urinary tract.

Pharmacokinetics

Absorption

Well absorbed from GI tract.

Elimination

10% to 30% excreted renally within 6 h; 57% excreted in 24 h.

Onset

55 min.

Peak

112 min.

Indications and Usage

Symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence associated with cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.

Contraindications

Pyloric or duodenal obstruction; obstructive intestinal lesions or ileus; achalasia; GI hemorrhage; obstructive uropathies of lower urinary tract.

Dosage and Administration

Adults and Children (older than 12 yr of age)

PO 100 to 200 mg 3 to 4 times/day.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Tachycardia; palpitations.

CNS

Nervousness; headache; drowsiness; mental confusion.

Dermatologic

Urticaria and other dermatoses.

EENT

Vertigo; blurred vision, ocular tension; disturbances in accommodation.

GI

Nausea; vomiting; dry mouth.

Genitourinary

Dysuria.

Hematologic

Eosinophilia; leukopenia.

Miscellaneous

High fever.

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Children

Safety and efficacy in children younger than 12 yr of age not established.

Glaucoma

Give cautiously to patients with suspected glaucoma.

Patient Information

Caution patient against performing potentially hazardous activities until effects of product are well-tolerated.
Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
Advise patient to report these symptoms to health care provider: persistent or worsening dry mouth, hives, rash, nausea or vomiting, unusual nervousness, vertigo, headache, drowsiness, confusion, high fever, dysuria, tachycardia, palpitations, vision problems.