(doe BYOO ta meen)
- Dobutamine Hydrochloride
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Intravenous, as hydrochloride:
Generic: 1 mg/mL (250 mL); 2 mg/mL (250 mL); 4 mg/mL (250 mL); 250 mg/20 mL (20 mL); 500 mg/40 mL (40 mL)
- Adrenergic Agonist Agent
Dobutamine, a racemic mixture, stimulates myocardial beta1-adrenergic receptors primarily by the (+) enantiomer and some alpha1 receptor agonism by the (-) enantiomer, resulting in increased contractility and heart rate, and stimulates both beta2- and alpha1-receptors in the vasculature. Although beta2 and alpha1 adrenergic receptors are also activated, the effects of beta2 receptor activation may equally offset or be slightly greater than the effects of alpha1 stimulation, resulting in some vasodilation in addition to the inotropic and chronotropic actions (Leier 1988; Majerus 1989; Ruffolo 1987). Lowers central venous pressure and wedge pressure, but has little effect on pulmonary vascular resistance (Leier 1977; Leier 1978).
In tissues and hepatically to inactive metabolites
Urine (as metabolites)
Onset of Action
IV: 1-10 minutes; Peak effect: 10-20 minutes
Use: Labeled Indications
Cardiac decompensation: Short-term management of patients with cardiac decompensation
American College of Cardiology/American Heart Association heart failure (HF) guideline recommendations (ACCF/AHA [Yancy 2013]): To maintain systemic perfusion and preserve end-organ performance in patients with cardiogenic shock; bridge therapy in stage D HF unresponsive to guideline-directed medical therapy and device therapy in patients awaiting heart transplant or mechanical circulatory support; short-term management of hospitalized patients with severe systolic dysfunction presenting with low blood pressure and significantly depressed cardiac output; long-term management (palliative therapy) in select patients with stage D HF unresponsive to guideline-directed medical therapy and device therapy who are not candidates for heart transplant or mechanical circulatory support.
Positive inotropic agent for use in myocardial dysfunction related to sepsis; stress echocardiography
Hypersensitivity to dobutamine or sulfites (some contain sodium metabisulfate), or any component of the formulation; Hypertrophic cardiomyopathy with outflow tract obstruction (formerly known as idiopathic hypertrophic subaortic stenosis [IHSS])
Note: When utilized for stress testing, additional contraindications according to the American Society of Nuclear Cardiology (ASNC) include patients with recent (<1 week) MI, unstable angina, severe aortic stenosis, atrial tachyarrhythmias with uncontrolled ventricular response, prior history of ventricular tachycardia, uncontrolled hypertension (>200/110 mm Hg), aortic dissection or large aortic aneurysm, and patients on beta blockers where heart rate and inotropic responses to dobutamine will be attenuated (ASNC [Henzlova 2009])
Cardiac decompensation: IV infusion: Children and Adults:
Initial dose: 0.5 to 1 mcg/kg/minute (per the manufacturer); may also initiate at higher doses (eg, 2.5 mcg/kg/minute) depending on severity of decompensation with titration to desired response (Leier 1977).
Maintenance dose: 2 to 20 mcg/kg/minute. Note: In patients with heart failure, lower doses are preferred to minimize adverse effects (ACCF/AHA [Yancy 2013]).
Maximum dose: 40 mcg/kg/minute. The ACCF/AHA 2013 heart failure guidelines and the Surviving Sepsis Campaign recommend a maximum dose of 20 mcg/kg/minute (ACCF/AHA [Yancy 2013]; SCCM [Dellinger 2013]).
Advanced life support:
Children: Pediatric Advanced Life Support (PALS) guideline recommendation (to maintain cardiac output and for postresuscitation stabilization): IV or I.O.: Dose range: 2 to 20 mcg/kg/minute (AHA [Kleinman 2010])
Adults: Adult Advanced Cardiovascular Life Support (ACLS) guideline recommendation (in the immediate post-cardiac arrest care setting): IV infusion: Initial: 5 to 10 mcg/kg/minute; titrate to effect (AHA [Peberdy 2010])
Stress echocardiography (diagnostic agent) (off-label use): Adults: IV infusion: Initial: 5 to 10 mcg/kg/minute; increase at 3-minute intervals to 20 mcg/kg/minute, then 30 mcg/kg/minute, and then 40 mcg/kg/minute. May coadminister atropine in patients who do not achieve target heart rate (ASNC [Henzlova 2009]).
Dosage adjustment in renal impairment: There are no dosage adjustments provided in the manufacturer’s labeling.
Dosage adjustment in hepatic impairment: There are no dosage adjustments provided in the manufacturer’s labeling.
Always administer via infusion device; administer into large vein.
Per manufacturer, do not give through same IV line as heparin, hydrocortisone sodium succinate, cefazolin, or penicillin. Incompatible with heparin, cefazolin, penicillin, and in alkaline solutions (sodium bicarbonate).
Stable in D5LR, D51/2NS, D5NS, D5W, D10W, LR, 1/2NS, NS, mannitol 20%; incompatible with sodium bicarbonate 5%; variable stability (consult detailed reference) in peritoneal dialysis solutions.
Y-site administration: Incompatible with acyclovir, alteplase, aminophylline, amphotericin B cholesteryl sulfate complex, foscarnet, indomethacin, micafungin, pemetrexed, pantoprazole, phytonadione, piperacillin/tazobactam, thiopental, warfarin.
Compatibility in syringe: Incompatible with doxapram, pantoprazole.
Store reconstituted solution under refrigeration for 48 hours or 6 hours at room temperature. Stability of parenteral admixture at room temperature (25°C) is 48 hours; at refrigeration (4°C) stability is 7 days. Remix solution every 24 hours. Pink discoloration of solution indicates slight oxidation but no significant loss of potency.
AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy
Calcium Salts: May diminish the therapeutic effect of DOBUTamine. Monitor therapy
Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. Monitor therapy
COMT Inhibitors: May decrease the metabolism of COMT Substrates. Monitor therapy
Doxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline. Monitor therapy
Iobenguane I 123: Sympathomimetics may diminish the therapeutic effect of Iobenguane I 123. Avoid combination
Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid. Specific dose adjustment recommendations are not presently available. Consider therapy modification
Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy
Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy
Incidence of adverse events is not always reported.
Cardiovascular: Ventricular premature contractions (5%; dose related), angina pectoris (1% to 3%), chest pain (1% to 3%; nonspecific), palpitations (1% to 3%), hypotension, increased blood pressure, increased heart rate, localized phlebitis, ventricular ectopy (increased)
Central nervous system: Headache (1% to 3%), paresthesia
Dermatologic: Skin necrosis (isolated cases)
Endocrine & metabolic: Decreased serum potassium (slight)
Gastrointestinal: Nausea (1% to 3%)
Hematologic & oncologic: Thrombocytopenia (isolated cases)
Local: Local inflammation, local pain (from infiltration)
Neuromuscular & skeletal: Leg cramps (mild)
Respiratory: Dyspnea (1% to 3%)
Miscellaneous: Fever (1% to 3%)
Concerns related to adverse effects:
• Arrhythmias: Ventricular arrhythmias, including nonsustained ventricular tachycardia and supraventricular arrhythmias, have been reported (Tisdale,1995). Observe closely for arrhythmias in patients with acute heart failure; sudden cardiac death has been observed (O’Connor 1999; Pickworth 1992; Young 2000). Ensure that ventricular rate is controlled in atrial fibrillation/flutter before initiating; may increase ventricular response rate. In heart transplant candidates, institute appropriate measures to protect patient against risks of sudden cardiac death (Young 2000).
• Blood pressure effects: An increase in blood pressure is more common due to augmented cardiac output, but occasionally a patient may become hypotensive.
• Heart failure complications: An increased risk of hospitalization and death has been observed with prolonged use in New York Heart Association Class III/IV heart failure patients (O’Connor 1999).
• Tachycardia: May cause dose-related increases in heart rate.
• Ventricular ectopy: May exacerbate ventricular ectopy (dose-related).
• Aortic stenosis: Ineffective therapeutically in the presence of mechanical obstruction such as severe aortic stenosis.
• Electrolyte imbalance: Correct electrolyte disturbances, especially hypokalemia or hypomagnesemia, prior to use and throughout therapy to minimize the risk of arrhythmias (ACC/AHA/ESC [Zipes 2006]; Tisdale 1995).
• Hypovolemia: If needed, correct hypovolemia first to optimize hemodynamics.
• Active myocardial ischemia/myocardial infarction (post): Use with caution in patients with active myocardial ischemia or recent myocardial infarction; can increase myocardial oxygen demand.
Concurrent drug therapy issues:
• Monoamine oxidase inhibitors (MAO-I): Use with extreme caution in patients taking MAO inhibitors; prolong hypertension may result from concurrent use.
Dosage form specific issues:
• Sodium sulfite: Product may contain sodium sulfite.
• Elderly: Use with caution in the elderly; start at lower end of the dosage range.
• Long-term therapy: According to the ACCF/AHA 2013 heart failure guidelines, long-term use of intravenous inotropic therapy without a specific indication or for reasons other than palliation is potentially harmful (ACCF/AHA [Yancy 2013]).
Blood pressure, ECG, heart rate, CVP, RAP, MAP; serum glucose, renal function; urine output; if pulmonary artery catheter is in place, monitor CI, PCWP, and SVR; ScvO2 or SvO2
Consult individual institutional policies and procedures.
Pregnancy Risk Factor
Adverse events have not been observed in animal reproduction studies. Dobutamine should not be used as a diagnostic agent during stress testing in pregnant women (Regitz-Zagrosek 2011).
• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
• Have patient report immediately to prescriber dyspnea, angina, tachycardia, arrhythmia, severe dizziness, syncope, significant asthenia, or considerable headache (HCAHPS).
• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.
Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.
More about dobutamine
- Dobutamine Hydrochloride (AHFS Monograph)
- Dobutamine (FDA)
- Dobutamine Injection (FDA)
- Dobutamine in Dextrose (FDA)
- Other brands: Dobutrex