Pronunciation: die-FLORE-ah-sone die-ASS-eh-tate
Class: Topical corticosteroid
- Cream 0.05%
- Ointment 0.05%
Therapeutic effects are caused by anti-inflammatory activity which are nonspecific (ie, they act against most causes of inflammation including mechanical, chemical, microbiological, and immunological).
Indications and Usage
Relief of the anti-inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
Dosage and Administration
Occlusive dressings may be used for certain conditions.Cream
Topical Apply sparingly to affected area 1 to 3 times/day.Ointment
Topical Apply sparingly to affected area 1 to 4 times/day.
None well documented.
Laboratory Test Interactions
None well documented.
These may occur more frequently with occlusive dressings.
Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hypopigmentation; perioral dermatitis; allergic contact dermatitis; skin maceration; secondary infection; skin atrophy; striae; miliaria.
Systemic absorption may produce reversible hypothalamic pituitary adrenal (HPA) axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glycosuria.
Category C .
Use with caution. It is not known whether topical corticosteroids could result in sufficient systemic absorption to produce adverse reactions in infants.
Children may be more susceptible to topical corticosteroid-induced HPA axis suppression and Cushing syndrome than adults because of larger skin surface area to body weight ratio.
Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, Cushing syndrome, hyperglycemia, and glycosuria. Conditions that may augment systemic absorption include use over large body surface areas, prolonged use, and occlusive dressings.
Copyright © 2009 Wolters Kluwer Health.
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