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Diflorasone Diacetate

Pronunciation: die-FLORE-ah-sone die-ASS-eh-tate
Class: Topical corticosteroid

Trade Names

Psorcon E
- Cream 0.05%
- Ointment 0.05%

Pharmacology

Therapeutic effects are caused by anti-inflammatory activity which are nonspecific (ie, they act against most causes of inflammation including mechanical, chemical, microbiological, and immunological).

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Indications and Usage

Relief of the anti-inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

Contraindications

Standard considerations.

Dosage and Administration

Occlusive dressings may be used for certain conditions.

Cream
Adult

Topical Apply sparingly to affected area 1 to 3 times/day.

Ointment
Adult

Topical Apply sparingly to affected area 1 to 4 times/day.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

These may occur more frequently with occlusive dressings.

Dermatologic

Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hypopigmentation; perioral dermatitis; allergic contact dermatitis; skin maceration; secondary infection; skin atrophy; striae; miliaria.

Miscellaneous

Systemic absorption may produce reversible hypothalamic pituitary adrenal (HPA) axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glycosuria.

Precautions

Pregnancy

Category C .

Lactation

Use with caution. It is not known whether topical corticosteroids could result in sufficient systemic absorption to produce adverse reactions in infants.

Children

Children may be more susceptible to topical corticosteroid-induced HPA axis suppression and Cushing syndrome than adults because of larger skin surface area to body weight ratio.

Systemic effects

Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, Cushing syndrome, hyperglycemia, and glycosuria. Conditions that may augment systemic absorption include use over large body surface areas, prolonged use, and occlusive dressings.

Copyright © 2009 Wolters Kluwer Health.

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