Diflorasone Diacetate
Pronunciation: die-FLORE-ah-sone die-ASS-eh-tate
Class: Topical corticosteroid
Trade Names
Psorcon E
- Cream 0.05%
- Ointment 0.05%
Pharmacology
Therapeutic effects are caused by anti-inflammatory activity which are nonspecific (ie, they act against most causes of inflammation including mechanical, chemical, microbiological, and immunological).
Indications and Usage
Relief of the anti-inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
Contraindications
Standard considerations.
Dosage and Administration
Occlusive dressings may be used for certain conditions.
CreamAdult
Topical Apply sparingly to affected area 1 to 3 times/day.
OintmentAdult
Topical Apply sparingly to affected area 1 to 4 times/day.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
These may occur more frequently with occlusive dressings.
Dermatologic
Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hypopigmentation; perioral dermatitis; allergic contact dermatitis; skin maceration; secondary infection; skin atrophy; striae; miliaria.
Miscellaneous
Systemic absorption may produce reversible hypothalamic pituitary adrenal (HPA) axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glycosuria.
Precautions
Pregnancy
Category C .
Lactation
Use with caution. It is not known whether topical corticosteroids could result in sufficient systemic absorption to produce adverse reactions in infants.
Children
Children may be more susceptible to topical corticosteroid-induced HPA axis suppression and Cushing syndrome than adults because of larger skin surface area to body weight ratio.
Systemic effects
Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, Cushing syndrome, hyperglycemia, and glycosuria. Conditions that may augment systemic absorption include use over large body surface areas, prolonged use, and occlusive dressings.
Copyright © 2009 Wolters Kluwer Health.
More Diflorasone Diacetate resources
- ApexiCon Concise Consumer Information (Cerner Multum)
- ApexiCon E Prescribing Information (FDA)
- Apexicon Advanced Consumer (Micromedex) - Includes Dosage Information
- Apexicon Prescribing Information (FDA)
- Apexicon cream MedFacts Consumer Leaflet (Wolters Kluwer)
- Florone Prescribing Information (FDA)
- Psorcon Monograph (AHFS DI)
- psorcon Prescribing Information (FDA)
