Ciprofloxacin Hydrochloride / Hydrocortisone
Pronouncation: (Sip-ROW-FLOX-uh-sin HIGH-droe-KLOR-ide/HIGH-droe-core-tih-sone)Class: Steroid and antibiotic combination
Trade Names:
Cipro HC Otic
- Suspension 2 mg ciprofloxacin, 10 mg hydrocortisone/mL
Pharmacology
Feedback for Ciprofloxacin Hydrochloride/Hydrocortisone
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Interferes with microbial DNA synthesis.
HydrocortisoneDepresses formation, release, and activity of endogenous mediators of inflammation as well as modifying body's immune response.
Indications and Usage
Treatment of acute otitis externa in adults and children caused by susceptible strains of Pseudomonas aeruginosa , Staphylococcus aureus , and Proteus mirabilis .
Contraindications
Viral infections of the external canal, including varicella and herpes simplex infections; perforated tympanic membrane; hypersensitivity to hydrocortisone, ciprofloxacin, or any member of the quinolone class of antimicrobial agents.
Dosage and Administration
Adults and Children (1 yr of age and older)Otic Instill 3 drops of suspension into affected ear twice daily for 7 days.
General Advice
- For otic use only. Not for oral, nasal, or ocular use.
- Hold bottle in hand for 1 to 2 min to warm suspension.
- Shake well immediately before using.
- Do not touch ear with dropper.
- Do not rinse dropper after use.
Storage/Stability
Store below 77°F. Avoid freezing. Protect from light.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
CNS
Headache; migraine.
Dermatologic
Pruritus; fungal dermatitis; rash; alopecia; urticaria.
Respiratory
Cough.
Miscellaneous
Hypesthesia; paresthesia.
Precautions
MonitorInfectionMonitor patient for improvement of symptoms of infection. SensitivityMonitor patient for sensitization or irritation and report to health care provider if noted. |
Pregnancy
Category C .
Lactation
Ciprofloxacin and hydrocortisone are excreted in breast milk following oral administration.
Children
Safety and efficacy in children 2 yr of age and older have been established; although no data are available on patients less than 2 yr of age, there are no known safety concerns or differences in the disease process in this population that would preclude use in patients 1 yr of age and older.
Hypersensitivity
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolones.
Superinfection
Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.
Bacterial resistance
Bacterial resistance to components of the product may develop.
Patient Information
- Remind patient, family, or caregiver that medication is for use in the ear only.
- Teach patient proper technique for instilling ear drops: Wash hands; warm solution by holding bottle in hand for 1 to 2 min; shake well. Tilt head to side or lie on side with affected ear upward; instill prescribed number of drops and maintain position for 30 to 60 sec to allow drops to penetrate ear canal. Repeat, if necessary, for the opposite ear. Do not allow dropper to touch ear; replace dropper.
- Advise patient, family, or caregiver to only use supplied dropper and not to rinse dropper after use.
- Advise patient, family, or caregiver to notify health care provider if symptoms do not improve or if irritation, inflammation, or itching of ear canal is noted.
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