Butoconazole Nitrate

Trade Names:
Femstat 3
- Vaginal cream 2%

Pharmacology

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Increases cell membrane permeability in susceptible fungi.

Indications and Usage

Local treatment of vulvovaginal candidiasis (moniliasis).

Contraindications

Hypersensitivity to imidazoles.

Dosage and Administration

Intravaginal 1 applicator (about 5 g) at bedtime for 3 days; may continue up to 6 days if needed.

Intravaginal Use only during second or third trimester, 1 applicator (about 5 g) at bedtime for 6 days.

Storage/Stability

Store at room temperature. Avoid heat above 40°C (104°F). Do not freeze.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Genitourinary

Vulvar/vaginal burning; urinary frequency.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Intractable candidiasis

May be symptom of unrecognized diabetes or reinfection; evaluate patient carefully.

Irritation or sensitization

If this occurs, discontinue use.

Patient Information

• Teach patient correct application technique.
• Instruct patient to use sanitary napkin to prevent staining clothing.
• Caution patient to refrain from sexual intercourse or advise partner to use condom to prevent reinfection.
• Explain importance of informing sexual partner of possible infection and of seeking appropriate medical treatment.
• Caution patient against using tampons during treatment.
• Tell patient to notify health care provider if any of the following symptoms occur after initiation of therapy: headache; body aches; local irritation, burning or rash; vaginal swelling or discharge; sensitivity to light.

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Vaginal Yeast Infection

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