Butoconazole Nitrate
Pronunciation: (BYOO-toe-KOE-nuh-zole NYE-trate)Class: Vaginal antifungal agent
Trade Names:
Femstat 3
- Vaginal cream 2%
Trade Names:
Mycelex-3
- Vaginal cream 2%
Pharmacology
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Increases cell membrane permeability in susceptible fungi.
Indications and Usage
Local treatment of vulvovaginal candidiasis (moniliasis).
Contraindications
Hypersensitivity to imidazoles.
Dosage and Administration
Nonpregnant WomenIntravaginal 1 applicator (about 5 g) at bedtime for 3 days; may continue up to 6 days if needed.
Pregnant WomenIntravaginal Use only during second or third trimester, 1 applicator (about 5 g) at bedtime for 6 days.
Storage/Stability
Store at room temperature. Avoid heat above 40°C (104°F). Do not freeze.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
Genitourinary
Vulvar/vaginal burning; urinary frequency.
Precautions
Pregnancy
Category C .
Lactation
Undetermined.
Children
Safety and efficacy not established.
Intractable candidiasis
May be symptom of unrecognized diabetes or reinfection; evaluate patient carefully.
Irritation or sensitization
If this occurs, discontinue use.
Patient Information
- Teach patient correct application technique.
- Instruct patient to use sanitary napkin to prevent staining clothing.
- Caution patient to refrain from sexual intercourse or advise partner to use condom to prevent reinfection.
- Explain importance of informing sexual partner of possible infection and of seeking appropriate medical treatment.
- Caution patient against using tampons during treatment.
- Tell patient to notify health care provider if any of the following symptoms occur after initiation of therapy: headache; body aches; local irritation, burning or rash; vaginal swelling or discharge; sensitivity to light.
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Butoconazole Nitrate Side Effects
