Butoconazole Nitrate
Pronunciation: BYOO-toe-KOE-nuh-zole NYE-trate
Class: Vaginal antifungal agent
Trade Names
Femstat 3
- Vaginal cream 2%
Mycelex-3
- Vaginal cream 2%
Pharmacology
Increases cell membrane permeability in susceptible fungi.
Grapefruit and grapefruit juice can react adversely with over 85 prescription medications.
Indications and Usage
Local treatment of vulvovaginal candidiasis (moniliasis).
Contraindications
Hypersensitivity to imidazoles.
Dosage and Administration
Nonpregnant WomenIntravaginal 1 applicator (about 5 g) at bedtime for 3 days; may continue up to 6 days if needed.
Pregnant WomenIntravaginal Use only during second or third trimester, 1 applicator (about 5 g) at bedtime for 6 days.
Storage/Stability
Store at room temperature. Avoid heat above 40°C (104°F). Do not freeze.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
Genitourinary
Vulvar/vaginal burning; urinary frequency.
Precautions
Pregnancy
Category C .
Lactation
Undetermined.
Children
Safety and efficacy not established.
Intractable candidiasis
May be symptom of unrecognized diabetes or reinfection; evaluate patient carefully.
Irritation or sensitization
If this occurs, discontinue use.
Patient Information
- Teach patient correct application technique.
- Instruct patient to use sanitary napkin to prevent staining clothing.
- Caution patient to refrain from sexual intercourse or advise partner to use condom to prevent reinfection.
- Explain importance of informing sexual partner of possible infection and of seeking appropriate medical treatment.
- Caution patient against using tampons during treatment.
- Tell patient to notify health care provider if any of the following symptoms occur after initiation of therapy: headache; body aches; local irritation, burning or rash; vaginal swelling or discharge; sensitivity to light.
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