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Butenafine Hydrochloride

Pronunciation: byoo-TEN-ah-feen HIGH-droe-KLOR-ide
Class: Antifungal agent

Trade Names

Lotrimin Ultra
- Cream 1%

Mentax
- Cream 1%

Pharmacology

Appears to inhibit biosynthesis of the ergosterol component of fungal cell membranes.

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Indications and Usage

Interdigital tinea pedis (athlete's foot); tinea corporis (ringworm); tinea cruris (jock itch); tinea (pityriasis) versicolor caused by susceptible organisms.

Contraindications

Standard considerations.

Dosage and Administration

Tinea Pedis
Adults and Children 12 yr of age and older

Topical Apply to affected and surrounding area(s) twice daily for 7 days or every day for 4 wk.

Tinea Corporis, Tinea Cruris, and Tinea (Pityriasis) Versicolor
Adults and Children 12 yr of age and older

Topical Apply every day for 2 wk.

General Advice

  • For topical use only. Not for ophthalmic, oral, or intravaginal use.
  • Avoid contact with eyes, eyelids, lips, and mucus membranes.
  • Apply enough cream to cover affected area(s) and the immediately surrounding skin and gently massage cream into skin.

Storage/Stability

Store at controlled room temperature or in refrigerator (41° to 86°F). Keep tube tightly capped.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Worsening of condition, burning, stinging, itching (1%).

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Children

Safety and efficacy in children younger than 12 yr of age not established.

Patient Information

  • Advise patient that medication is applied topically to skin lesions every day or twice daily.
  • Teach patient proper technique for applying cream: wash hands; ensure that area to be treated is dry; apply a thin film of cream to cover affected area(s) and immediately surrounding skin areas; gently massage into skin; wash hands after applying medication.
  • Advise patient that improvement may take several days to weeks to occur and to continue applying the medication for entire treatment time recommended by health care provider.
  • Instruct patient to notify health care provider if improvement is not noted after the end of the treatment period, or sooner if condition worsens.
  • Caution patient not to cover treated areas with bandages or dressings unless advised by health care provider.
  • Advise patient that if an application is missed to not try to make it up but to return to normal application schedule as soon as possible.
  • Warn patient to avoid contact with the eyes, eyelids, lips, and mucous membranes.
  • Advise patient that if cream comes in contact with the eyes to wash eyes with large amounts of cool water and to contact health care provider if eye irritation persists.
  • Advise patient that local stinging, burning, itching, and redness are most common adverse reactions and to notify health care provider if they become bothersome.
  • Advise patient to stop using the medication and contact health care provider if severe skin reactions occur (eg, blistering, swelling, oozing).

Copyright © 2009 Wolters Kluwer Health.

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