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Bisacodyl

Pronunciation

Pronunciation: BISS-uh-koe-dill
Class: Laxative

Trade Names

Dulcolax
- Tablets, enteric-coated 5 mg
- Suppositories 10 mg

Fleet Laxative
- Tablets, enteric-coated 5 mg
- Suppositories 10 mg

Modane
- Tablets, enteric-coated 5 mg

Women's Gentle Laxative
- Tablets, enteric-coated 5 mg

Bisac-Evac
- Tablets, enteric-coated 5 mg
- Suppositories 10 mg

Caroid
- Tablets, enteric-coated 5 mg

Correctol
- Tablets, enteric-coated 5 mg

Feen-a-mint
- Tablets, enteric-coated 5 mg

Reliable Gentle Laxative
- Tablets, enteric-coated and delayed-release 5 mg
- Suppositories 10 mg

Bisacodyl Uniserts
- Suppositories 10 mg

APO-Bisacodyl (Canada)
Apo-Bisacodyl DR (Canada)
Carters Little Pills (Canada)
ratio-Bisacodyl (Canada)

Pharmacology

Acts as cathartic stimulant.

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Pharmacokinetics

Onset

Tablets

6 to 10 h.

Suppositories

15 to 60 min.

Indications and Usage

Short-term treatment of constipation; evacuation of colon for rectal and bowel evaluations; preparation for delivery or surgery.

Contraindications

Nausea, vomiting, or other symptoms of appendicitis; acute surgical abdomen; fecal impaction; intestinal obstruction; undiagnosed abdominal pain; ulcerative lesions of colon; rectal fissures; ulcerative hemorrhoids.

Dosage and Administration

Oral
Adults

PO 10 to 15 mg.

Preparation of Lower GI Tract

Up to 30 mg.

Children older than 6 yr of age

PO 5 to 10 mg (0.3 mg/kg).

Suppository
Adults

PR 10 mg.

Children older than 2 yr of age

PR 10 mg.

Children younger than 2 yr of age

PR 5 mg.

Storage/Stability

Store tablets and suppositories in tightly closed containers in cool location.

Drug Interactions

Milk or antacids

May cause enteric coating of tablets to dissolve, resulting in gastric lining irritation or gastric indigestion.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Palpitations.

CNS

Dizziness, fainting.

GI

Excessive bowel activity (griping, diarrhea, nausea, vomiting); perianal irritation; bloating; flatulence; abdominal cramping; proctitis and inflammation.

Miscellaneous

Sweating, weakness. Suppositories may cause proctitis and inflammation with long-term use.

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Children

Tablet form not recommended for children younger than 6 yr of age.

Drug dependency

Long-term use may lead to laxative dependency. Long-term abuse results in cathartic colon (poorly functioning colon).

Rectal bleeding or failure to produce bowel movement

May indicate serious condition that may require further medical attention.

Patient Information

  • Inform patient not to take bisacodyl when constipation is accompanied by abdominal pain, fever, nausea or vomiting.
  • Advise patient to use laxative only for short-term therapy; do not use for more than 1 wk.
  • Caution patient that prolonged, frequent, or excessive use of drug may result in dependence and/or electrolyte imbalance.
  • Encourage patient to incorporate high-fiber foods in diet, increase fluid intake (at least 6 to 8 glasses daily) and increase or maintain exercise level.
  • Instruct patient to report the following symptoms to health care provider: unrelieved constipation, rectal bleeding, muscle cramps, pain, weakness, dizziness.

Copyright © 2009 Wolters Kluwer Health.

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