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Betamethasone / Clotrimazole

Pronunciation: BAY-tuh-METH-uh-zone/kloe-TRIM-uh-zole
Class: Corticosteroid/Antifungal combination

Trade Names

Lotrisone
- Cream 0.05% betamethasone (as dipropionate)/1% clotrimazole
- Lotion 0.05% betamethasone (as diproprionate)/1% clotrimazole

Lotriderm (Canada)

Pharmacology

Clotrimazole increases cell membrane permeability in susceptible fungi. Betamethasone has anti-inflammatory, antipruritic, and vasoconstrictive actions.

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Indications and Usage

Topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum , T. mentagrophytes , Epidermophyton floccosum .

Contraindications

Hypersensitivity to clotrimazole, betamethasone dipropionate, or other corticosteroids or imidazoles, or to any ingredient in these preparations.

Dosage and Administration

Topical 1 application twice daily (2 wk for tinea cruris and tinea corporis; 4 wk for tinea pedis).

General Advice

  • Apply medication sparingly and rub in lightly.
  • Avoid contact with eyes, mouth, and nose.
  • Do not cover treated area with dressings or use tight-fitting diapers, plastic pants, or underwear over treated area.
  • Shake lotion well before use.

Storage/Stability

Store between 59° and 86°F. Store lotion in the upright position.

Drug Interactions

None well documented.

Adverse Reactions

CNS

Paresthesias (2%).

Dermatologic

Burning, dry skin (2%); local cutaneous reactions, including skin atrophy.

Miscellaneous

Growth retardation, benign intracranial hypertension, Cushing syndrome (HPA axis suppression).

Precautions

Monitor

Monitor treated sites for irritation or signs of secondary infection, and report any adverse reactions to health care provider. Monitor patients applying the cream or lotion to large areas or to areas under occlusion periodically for evidence of HPA axis suppression.


Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established in patients younger than 17 y or in patients with diaper dermatitis.

Elderly

Use with caution on thinning skin.

Adrenal suppression

Patients who receive large doses over large surface areas may experience HPA axis suppression. Cushing syndrome, hyperglycemia, and glucosuria may occur.

Occlusion

The use of these products under occlusion, such as diaper dermatitis, is not recommended.

Ophthalmic use

Do not use for eye infections.

Patient Information

  • Remind patient that medication is for external application only and to avoid contact with eyes, nose, and mouth.
  • Tell patient to notify health care provider if there is no improvement after 1 wk for tinea cruris or tinea corporis or after 2 wk for tinea pedis.
  • Caution patient against using dressings, tight-fitting diapers, or plastic pants over treated area.
  • Tell patients with tinea corporis (ringworm) to wash clothes separately from those of other family members.
  • When using these product in the groin area, advise patients to use for only 2 wk and to apply sparingly.
  • Remind patient to wash hands before and after each application of product.
  • Advise patient to complete prescribed treatment, even if infection clears, to prevent relapse.
  • Instruct patient to report the following symptoms to health care provider: burning, itching, rash, swelling, redness or blistering in treated area.

Copyright © 2009 Wolters Kluwer Health.

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