Get Expert Advice for controlling your Severe Allergies

Bepotastine Besilate

Pronunciation: BEP-oh-TAS-teen BES-il-ate
Class: Mast cell stabilizer

Trade Names

Bepreve
- Solution, ophthalmic 1.5%

Pharmacology

A highly selective histamine H 1 antagonist that inhibits the release of histamine from mast cells.

Slideshow: Fact or Fiction? The Top 15 Osteoarthritis Myths

Pharmacokinetics

Absorption

T max is 1 to 2 h; C max is approximately 7.3 ng/mL.

Distribution

Protein binding is approximately 55%.

Metabolism

Not extensively metabolized.

Elimination

Approximately 75% to 90% excreted unchanged in the urine.

Indications and Usage

Temporary relief of itching caused by allergic conjunctivitis.

Contraindications

Standard considerations.

Dosage and Administration

Adults and Children 2 yr of age and older

Ophthalmic 1 drop in affected eye(s) twice daily.

General Advice

  • For topical ophthalmic use only.
  • Do not instill while wearing contact lenses. Lenses may be reinserted 10 min following administration.

Storage/Stability

Store between 59° and 77°F. Keep bottle tightly closed.

Drug Interactions

Laboratory Test Interactions

None well documented.

Adverse Reactions

CNS

Headache (2% to 5%).

EENT

Eye irritation, nasopharyngitis (2% to 5%).

Miscellaneous

Mild taste (25%).

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and effectiveness in children younger than 2 yr of age have not been established.

Elderly

No differences in safety or effectiveness have been observed.

Patient Information

  • Advise patient that usual dose is 1 drop in affected eye(s) twice daily.
  • Teach patient proper technique for instilling eye drops: wash hands; do not allow dropper to touch eye; tilt head back and look up; pull lower eyelid down; instill prescribed number of drops; close eye for 1 to 2 min and apply gentle pressure to bridge of nose; do not rub eye.
  • Advise patients who wear contact lenses to remove their lenses before instilling this medicine and to wait at least 10 min after instilling eye drop before inserting their lenses. Also, caution these patients not to wear their lens if eye is red.
  • Advise patient to inform health care provider if experiencing side effects, or if eye symptoms do not improve or they worsen.

Copyright © 2009 Wolters Kluwer Health.

Hide
(web1)