Bacitracin Zinc / Neomycin Sulfate / Polymyxin B Sulfate / Hydrocortisone
Pronunciation: Bass-ih-TRAY-sin zingk/NEE-oh-MY-sin SULL-fate/pal-ee-MIX-in BEE SULL-fate/HIGH-droe-CORE-tih-sone
Class: Antibiotic, Corticosteroid
Trade Names
Cortisporin
- Ointment 400 units/g bacitracin zinc, 3.5 mg/g neomycin, 5,000 units/g polymyxin B, 1% hydrocortisone
Pharmacology
NeomycinInhibits protein synthesis by binding to ribosomal RNA, causing bacterial genetic code misreading.
Polymyxin BInteracts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.
Interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with paptidoglycan synthesis.
HydrocortisoneSuppresses inflammatory response.
Indications and Usage
Treatment of corticosteroid-responsive dermatoses with secondary infection.
Contraindications
Use in the eyes or external ear canal (if the eardrum is perforated); tuberculosis; fungal or viral (eg, varicella zoster) lesions of the skin; hypersensitivity to any of components of product.
Dosage and Administration
Topical Apply thin film to affected area 2 to 4 times daily, not to exceed 7 days.
Storage/Stability
Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.
Drug Interactions
None well documented.
Laboratory Test Interactions
None well documented.
Adverse Reactions
Dermatologic
Acneiform eruption, allergic contact dermatitis, burning, dryness, folliculitis, hypertrichosis, hypopigmentation, itching, maceration of the skin, miliaria, perioral dermatitis, secondary infection, skin atrophy, skin sensitization, striae.
EENT
Ototoxicity.
Genitourinary
Nephrotoxicity.
Miscellaneous
Allergic sensitivity.
Precautions
Pregnancy
Category C .
Lactation
Hydrocortisone is excreted in breast milk following oral administration.
Children
Safety and efficacy in children not established.
Superinfection
Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.
Adrenal suppression
Signs and symptoms of exogenous hyperadrenocorticism can occur with use of topical corticosteroids, especially if occlusive dressings are used.
Bacterial resistance
Bacterial resistance to components of the product may develop.
Patient Information
- Review prescribed dosing schedule with patient or caregiver.
- Remind patient or caregiver that ointment is not to be used in the eye or ear (if the eardrum is perforated).
- Teach patient or caregiver proper technique for applying ointment: Wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after applying ointment.
- Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.
Copyright © 2009 Wolters Kluwer Health.
