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Alclometasone Dipropionate

Pronunciation: al-kloe-MEH-tah-zone die-PRO-pee-oh-nate
Class: Corticosteroid, topical

Trade Names

Aclovate
- Cream 0.05%
- Ointment 0.05%

Pharmacology

Topical glucocorticoid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Thought to act by inducing phospholipase A 2 inhibitory proteins, thus controlling biosynthesis of potent mediators of inflammation.

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Indications and Usage

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Contraindications

Standard considerations.

Dosage and Administration

Adults and Children older than 1 yr of age

Topical Apply thin film to affected area 2 to 3 times daily.

Storage/Stability

Store cream and ointment in refrigerator (36° to 46°F) or at ambient room temperature (below 86°F). Keep tube tightly capped.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Itching, burning, erythema, dryness, irritation, papular rashes (2%).

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

May be used with caution in children older than 1 yr of age, although the safety and efficacy of drug use for more than 3 wk not established. Children may absorb proportionally larger amounts of topical corticosteroids and, therefore, be more susceptible to systemic toxicity. Use is not recommended in children younger than 1 yr of age. Children are at higher risk than adults of hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing syndrome when they are treated with topical corticosteroids. Do not use to treat diaper rash.

Systemic

Systemic absorption may produce HPA axis suppression and systemic adverse reactions, particularly when used over 20% of body surface area. Ensure that patient applying medication to a large surface area, or to areas under occlusion, is periodically evaluated for evidence of HPA axis suppression (eg, adrenocorticotropic hormone stimulation, morning plasma cortisol, urinary free cortisol tests).

Patient Information

  • Teach patient or caregiver proper technique for applying cream or ointment: Wash hands; apply sufficient cream or ointment to cover affected areas sparingly and gently massage into skin; wash hands after applying cream or ointment.
  • Advise patient to apply cream or ointment to affected areas 1 to 3 times a day as directed by health care provider.
  • Advise patient that if a dose is missed, to apply it as soon as remembered and then continue on the regular schedule. If it is almost time for the next application, instruct patient to skip the dose and continue on the regular schedule. Caution patient not to apply double doses.
  • Caution patient not to apply to face, underarms, or groin area unless directed by health care provider.
  • Caution patient not to bandage, cover, or wrap treated skin areas or use cosmetics or other skin products over treated areas unless advised by health care provider.
  • Caution patient to avoid contact with eyes. Advise patient that if cream does come into contact with the eyes, to wash eyes with large amounts of cool water and contact health care provider if eye irritation occurs.
  • Caution parents of children not to use alclometasone cream or ointment to treat diaper rash.
  • Advise patient that symptoms should begin to improve fairly soon after starting treatment and to notify health care provider if condition does not improve, worsens, or if application-site reactions (eg, burning, stinging, redness, itching) develop.
  • Advise patient that therapy is usually discontinued when control has been achieved.

Copyright © 2009 Wolters Kluwer Health.

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