Generic Name: felodipine (fe LOE di peen)
Brand Names: Plendil

What is Plendil?

Plendil (felodipine) is in a class of drugs called calcium channel blockers. Felodipine relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Plendil is used to treat hypertension (high blood pressure).

Plendil may also be used for other purposes not listed in this medication guide.

Important information

You should not use Plendil if you are allergic to felodipine.

Before taking Plendil, tell your doctor if you have liver disease or congestive heart failure.

Many drugs can interact with Plendil. Tell your doctor about all other medications you use.

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Your blood pressure will need to be checked often and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Keep using Plendil as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Brush and floss your teeth regularly while taking this medication. Plendil can cause mild swelling of your gums, which may be avoided with good dental hygiene.

Before taking this medicine

You should not use Plendil if you are allergic to felodipine.

If you have any of these other conditions, your doctor may need to adjust your Plendil dose or order special tests:

  • liver disease; or
  • congestive heart failure.

FDA pregnancy category C. It is not known whether Plendil will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Plendil. It is not known whether felodipine passes into breast milk or if it could harm a nursing baby. Do not use Plendil without telling your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I take Plendil?

Take Plendil exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

You make Plendil without food or a light meal, but take it the same way each time.

Do not crush, chew, or break an extended-release Plendil tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. These conditions can lead to severely low blood pressure.

Your blood pressure will need to be checked often and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Keep using Plendil as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Brush and floss your teeth regularly while taking Plendil. Felodipine can cause mild swelling of your gums, which may be avoided with good dental hygiene.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe dizziness, slow heart rate, redness or tingling in your arms and legs, and feeling like you might pass out.

What should I avoid?

Grapefruit and grapefruit juice may interact with Plendil and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can lower your blood pressure further and may increase certain side effects of Plendil.

Plendil side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Plendil: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;

  • feeling short of breath, swelling in your hands or feet;

  • fast or pounding heartbeats;

  • numbness or tingly feeling; or

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious Plendil side effects may include:

  • headache, dizziness, drowsiness, weakness;

  • feeling restless or nervous;

  • nausea, upset stomach, constipation, diarrhea, stomach pain;

  • sleep problems (insomnia);

  • joint pain or muscle cramps;

  • warmth, redness, or tingly feeling under your skin;

  • mild rash;

  • urinating more than usual; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of Plendil side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Plendil?

Tell your doctor about all other medicines you use, especially:

  • cimetidine (Tagamet);

  • conivaptan (Vaprisol);

  • imatinib (Gleevec);

  • isoniazid (for treating tuberculosis);

  • tacrolimus (Prograf);

  • an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

  • antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

  • an antidepressant such as nefazodone;

  • a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others;

  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir);

  • other heart or blood pressure medications such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others; or

  • seizure medication such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Solfoton), or phenytoin (Dilantin).

This list is not complete and other drugs may interact with Plendil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Plendil.
  • Remember, keep this and all other medicines out of the reach of children. Never share your medicines with others and only use this medication for the condition prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 7.01. Revision Date: 03/10/2010 3:11:34 PM.

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