Scientific Name(s): Scoparia dulcis L. Family: Scrophuraliaceae
Sweet broomweed has been investigated for its antimalarial, antiulcer, antipyretic, and aphrodisiac activity as well as for its cytotoxic activity against cancer cells.
None suggested because of the lack of clinical data. S. dulcis is available commercially in combination with other herbs. It is available in tablet, capsule, and powder doseforms.
Contraindications have not been identified.
Avoid use because of the lack of clinical data regarding safety and efficacy in pregnancy and lactation.
None well documented.
The plant species is associated with sympathomimetic effects.
Scoparia has been used as a remedy for treating diabetes mellitus in India and hypertension in Taiwan. Traditionally, the fresh or dried plant has been used as a remedy for treating stomach ailments, hypertension, diabetes, inflammation, bronchitis, hemorrhoids, and hepatosis, and as an analgesic and antipyretic agent. 1 , 4
A hot water infusion and/or decoction of the leaves or whole plant is used medicinally by indigenous tribes of Nicaragua to treat malaria, stomach disorders, menstrual disorders, insect bites, fevers, heart problems, liver disorders, and venereal disease. It has been used for blood cleansing, as an aid to child-birth, and as a general tonic. 3
The herb is used in Brazilian folk medicine to treat bronchitis, gastric disorders, hemorrhoids, insect bites, and skin wounds. The herb is used in Asian medicine to treat hypertension. 5
The ethnoveterinary use of the plant dates back to 1889 in Trinidad as a topical lotion to treat impetigenous and herpetic eruptions. Many of the indications for the plant's use parallel those practiced in veterinary folk medicine. Mucilage is released when the whole plant is soaked in water, thus helping to protect and regenerate normal cells; it may also act as an immunostimulator. The plant has been used to treat skin rashes in Martinique and Trinidad, for irritated skin in Brazil, and as a multi-ingredient preparation for treating burns in eastern Nicaragua. In Paraguay, the plant is used to kill lice and fleas, and used against vermin. The plant is also valued for its analgesic, anti-inflammatory, anticancer, and antiviral activity. 6
The scientific literature reveals numerous chemical studies on the herb; isolated chemical constituents include coumarins, phenols, saponins, tannins, amino acids, flavonoids, terpenoids, and catecholamines. 4
High-performance liquid chromatographic analysis of an aqueous fraction of S. dulcis revealed the presence of noradrenaline and adrenaline, which have sympathomimetic effects. 5
The herb's terpenoids are responsible for numerous medicinal effects. Scoparic acid A, scoparic acid B, scopadulcic acid A and B, scopadulciol, and scopadulin are all biologically active. These chemical compounds have various biological activities, including inhibition of the replication of herpes simplex virus, inhibition of proton pumps, potassium adenosine triphosphate (ATP)ase activator, and antitumor promoting activity. Additional identified terpenoids of broomweed include alpha-amyrin, betulinic acid, dulcioic acid, friedelin, glutinol, and ifflaionic acid. 1 , 3 , 7 , 8 , 9 , 10
The acetylated flavone glycosides from broomweed have nerve growth factor (NGF)-potentiating activity or neurotrophic activity that may be useful in treating neurological disorders. The flavone glycosides, including isovitexin, also inhibit β-glucuronidase. 11 , 12
The dried roots and aerial parts of S. dulcis contain economically important hydroxamic acids, which provide insect, fungal, and bacterial resistance. 13
Uses and Pharmacology
Antimalarial, antiulcer, antipyretic, and aphrodisiac activities, as well as cytotoxicity activity against cancer cells, have been investigated.Analgesic and anti-inflammatory activity
The diterpene scoparinol demonstrated significant analgesic ( P < 0.001) and anti-inflammatory activity ( P < 0.01) in animals. 14
Pretreatment of ethanolic extracts of S. dulcis (0.5 g/kg) reduced acetic acid-induced writhing in mice 47%. The extract (0.5 and 1 g/kg) also inhibited paw edema in rats induced by carrageenan 46% and 58%, respectively, after 2 hours. The triterpene glutinol (30 mg/kg) reduced writhing in mice induced by acetic acid 40% and paw edema in rats induced by carrageenan 73%, indicating that the analgesic activity of S. dulcis is most likely related to the anti-inflammatory activity of glutinol. 15Neurotrophic activity
In vitro data
The acetylated flavone glycosides from S. dulcis have NGF-potentiating activity, which may be useful in treating neurological disorders.
In control experiments, following incubation, the percentages of neurite-bearing cells in PC12D cells were 27% with 2 ng/mL NGF and 71% with 30 ng/mL NGF after 48 hours. After incubation with the glycosides from S. dulcis , neurite outgrowth in PC12D cells was increased by an additional 16% and 15%, respectively. 11 , 16Antiviral activity
The diterpenoid scopadulcic acid B inhibited viral replication of herpes simplex virus type 1 in a hamster test model. The mechanism of action is unknown but does not involve a direct virucidal effect or inhibition of virus attachment. Topical application or intraperitoneal injections at 100 and 200 mg/kg/day prolonged the development of herpetic lesions and survival time when treatment was initiated immediately after virus inoculation. 17 , 18Antimalarial activity
The diterpenoid scopadulcic acid A has activity against various Plasmodium falciparum isolates with an IC50 of 27 mcM against the D6 clone (African Sierra isolate) and an IC50 of 19 mcM against the W2 clone (Indochina isolate). The IC50 against the multidrug-resistant TM91C235 (Thailand) isolate was 23 mcM. For comparison, IC50 values for chloroquine were 9.3, 266, and 24 nM against D6, W2, and TM91C235. The IC50 values for mefloquine were 36, 4.8, and 59 nM against D6, W2, and TM91C235. 1GI activity
The mechanism of action of the diterpenoid scopadulcic acid B and its debenzoyl derivative, diacetyl scopadol (DAS) involves inhibition of K+-dependent dephosphorylation of proton pumping for gastric acid secretion. 18In vitro
Scopadulcic acid B and its debenzoyl derivative, DAS, dose-dependently and specifically inhibited the ATP hydrolysis by gastric H+K-ATPase (proton pump for gastric acid secretion) but not Na+K+-ATPase activity. With respect to activating the cation K+, scopadulcic acid B is considered a mixed inhibitor, while DAS is considered an uncompetitive inhibitor. This action differs from the irreversible inhibitor omeprazole. Detailed mechanisms and specific inhibition effects in the catalytic reaction of scopadulcic acid B and DAS are provided in the study. 2 , 19Anticancer activity
In vitro and in vivo
Scopadulcic acid B inhibited the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Scopadulcic acid B also inhibited TPA-enhanced phospholipid synthesis in cultured cells and inhibited the effect of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene. 20
Four new labdane-derived diterpenes, isolated from the aerial parts of S. dulcis , were cytotoxic against the following 6 human stomach cancer cell lines: SCL, SCL-6, SCL-37′6, SCL-9, Kato-3, and NUGC-4. Vinblastine sulfate and mitomycin C were used as positive controls. 21
Scopadulcic acid C, another diterpene, enhanced the antitumor efficacy of acyclovir and ganciclovir in a HSV-TK gene therapy system. The synergistic activity was caused by the activation of viral thymidine kinase. 22 , 23Diabetes
Treatment with aqueous S. dulcis extracts and glibenclamide significantly improved specific insulin binding in streptozotocin-induced male Wistar rats. The number of insulin receptors and affinity binding ( P < 0.001) was reduced to normal nondiabetic levels. Overall, the results suggest an increase in total endoplasmic reticulum (ER) membrane insulin binding sites with a concomitant increase in plasma insulin in rats treated with aqueous S. dulcis extract or glibenclamide. The mean specific binding of insulin to ER was lower in diabetic control rats (55 +/- 2.8%) than in aqueous S. dulcis -treated (70 +/- 3.5%) and glibenclamide-treated (65 +/- 3.3%) diabetic rats, resulting in a decrease in plasma insulin. 24
An aqueous extract of S. dulcis plant was administered orally for 6 weeks to streptozotocin diabetic rats. The level of plasma insulin was decreased, and the levels of blood glucose and plasma glycoproteins were increased in diabetic control rats. The diabetic control rats also had a decrease in the level of sialic acid and elevated levels of hexose, hexosamine, and fucose in the liver and kidney. After oral administration of S. dulcis plant extracts, the controls had decreased levels of blood glucose and plasma glycoproteins. Plasma insulin and tissue sialic acid levels were increased, and hexose, hexosamine, and fucose tissue levels were near normal in controls. 25
Similar animal experiments using aqueous S. dulcis extracts of 200 mg/kg/day resulted in antihyperglycemic effects, including increased hemoglobin levels, decreases in hemoglobin A 1c levels, increased sorbitol dehydrogenase, lipid peroxidation, and antioxidant activity in the liver of diabetic rats. 26
Several animal studies documented the antioxidant activity of the plant, particularly against lipidperoxidation-induced membrane damage. A typical dosage regimen of an aqueous S. dulcis extract of 200 mg/kg/day resulted in an increase in the activities of pancreatic superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase, and reduced glutathione. 27 , 28 , 29Other pharmacological activity
In an animal study, an aqueous fraction of S. dulcis revealed the presence of 2 catecholamines, noradrenaline and adrenaline, that may account for the hypertensive and inotropic effects after parenteral administration. 5
A significant effect on onset and duration of sleep ( P < 0.05) was caused by scoparinol on pentobarbital-induced sedation in animals. In another animal study, sleeping time induced by sodium pentobarbital 50 mg/kg was prolonged 2-fold in mice pretreated with 0.5 g/kg of an ethanolic extract of S. dulcis . Scoparinol has a diuretic action in animals as demonstrated by the measurement of urine volume after administration. 14 , 15
None suggested because of the lack of clinical data on which to base a recommendation. Commercially, S. dulcis is often sold in combination with other herbs. It is available in tablet, capsule, and powder doseforms.
Avoid use because of the lack of clinical data regarding safety and efficacy in pregnancy and lactation. An aqueous fraction of S. dulcis contained catecholamines, noradrenaline and adrenaline, that may account for the sympathomimetic effects of the plant. 5
Scopadulcic acid C, a diterpene from S. dulcis , enhanced the antitumor efficacy of acyclovir and ganciclovir in a HSV-TK gene therapy system. Patients diagnosed with cardiovascular disease should avoid use because the aqueous fraction of S. dulcis revealed the presence of 2 catecholamines that may account for its hypertensive and inotropic effects. Avoid use or monitor therapy if using proton pump inhibitors (omeprazole [ Prilosec ]) or antacids because of the potential drug-drug interaction if also consuming any of the commercially available products containing S. dulcis . Avoid use or monitor therapy if diagnosed with diabetes and/or using insulin products. 5 , 22 , 23
The plant species is associated with sympathomimetic effects.
None suggested because of the lack of clinical data.
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